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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۱۱، صفحات ۱۱۷۰-۱۱۸۰
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عنوان انگلیسی Anti-Aging Effects of Some Selected Iranian Folk Medicinal Herbs-Biochemical Evidences
چکیده انگلیسی مقاله Objective(s): In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. Materials and Methods: Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/kg/day for 6 weeks). A positive control group was assigned that received vitamin E (200 mg/kg/day). The extract of herbs was prepared, lyophilized, and used in this study. The herbs were administered by gavage for 4 weeks to D-galactose-aged animals at the selected doses (mg/kg/day) as follows: Zingiber officinale (250), Glycyrrhiza glabra (150), Rosmarinus officinalis (300), Peganum harmala (50), Aloe vera (150), Satureja hortensis (200), Teucrium scordium (200), Hypericum perforatum (135) and Silybum marianum (150). One group of animals was assigned as sham and not given D-galactose. Results: At the end of treatment, pro-inflammatory markers including tumor necrosis factor-α (TNF-α), interlukine-1β (IL-β), interlukine-6 (IL-6), NF-kappaB (NF-κb), total antioxidant power (TAP), thiobarbituric acid reactive substances (TBARS) as lipid peroxidation (LPO) marker and male sex hormones i.e. testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were measured in the blood. Conclusion: These data for the first time indicate significant anti-aging potential of examined herbs. Results showed that D-galactose induces a significant oxidative stress and promotes proinflammatory cascade of aging while all herbs more or less recovered these changes. Among 9 herbal extracts, Silybum marianum showed the best effect in restoring aging changes.
کلیدواژه‌های انگلیسی مقاله Aging D-galactose Herbal Mouse Oxidative stress
نویسندگان مقاله آزاده محمدی راد | azadeh mohammadirad
department of toxicology and pharmacology, faculty of pharmacy, and pharmaceutical sciences research center, tehran university of medical sciences tums , tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه aghamohammadali صراف | fatemeh aghamohammadali sarraf
pharmaceutical sciences branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سیمین بدیعی | simin badiei
pharmaceutical sciences branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

زکیه فرجی | zakie faraji
pharmaceutical sciences branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

رضا حاجی آقایی | reza hajiaghaee
pharmacognosy amp;amp; pharmaceutics department of medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

مریم بعیری | maryam baeeri
department of toxicology and pharmacology, faculty of pharmacy, and pharmaceutical sciences research center, tehran university of medical sciences tums , tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهدی غلامی | mahdi gholami
department of toxicology and pharmacology, faculty of pharmacy, and pharmaceutical sciences research center, tehran university of medical sciences tums , tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد عبداللهی | mohammad abdollahi
department of toxicology and pharmacology, faculty of pharmacy, and pharmaceutical sciences research center, tehran university of medical sciences tums , tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_1935.html
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