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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۱۰، صفحات ۱۰۵۵-۱۰۶۴
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عنوان انگلیسی The Effects of Pyridaben Pesticide on the Histomorphometric, Hormonal Alternations and Reproductive Functions of BALB/c Mice
چکیده انگلیسی مقاله Objective(s): The adverse effects of pyridaben on reproductive system in male animals are not well established. This study was designed to elucidate how pyridaben can effects the histomorphometric, hormonal alternations and reproductive functions of BALB/c mice . Materials and Methods : For this study, 80 adult and apparently healthy male BALB/c mice were divided into three groups Viz, control, test group 1 and test group 2. Test groups 1 and 2 were received the toxin at doses of 53 mg/kg. BW, and 212 mg/kg. BW, respectively. The experiment period for both groups was 10, 25 and 45 days. Results : The levels of FSH, LH and testosterone were significantly (P< 0.05) decreased on the dose and time dependant means. The levels of the ROS and NOS were significantly (P< 0.05) increased in all test groups. The percent body weight gains significantly (P< 0.05) reduced, whereas weights significantly (P< 0.05) increased in test groups in a dose and time dependant manner. The histomorphometric and stereologic findings, including diameters of somniferous tubules, thickness of somniferous tubules epithelium, the leydig's cell distribution, TDI, SI, RI revealed that, all these parameters are also significantly (P< 0.05) reduces in test groups in a dose and time dependant manner. C onclusion: Pyridaben causes histomorphometric and stereologic changes in testis, as well as hormonal and reproductive functional alternations in BALB/c mice.
کلیدواژه‌های انگلیسی مقاله Hormones Male mouse Pyridaben Reproduction ROS NOS
نویسندگان مقاله قدرت عبادی مناس | ghodrat ebadi manas
department of biology, science and research branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

شاپور حسن زاده | shapour hasanzadeh
department of basic veterinary sciences, histology and embryology sections, faculty of veterinary medicine, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

کاظم پریور | kazem parivar
department of biology, science and research branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_1867.html
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زبان مقاله منتشر شده en
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