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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۶، صفحات ۷۴۳-۷۵۰
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عنوان انگلیسی Relationship of Dopamine of the Nucleus Accumbens with Intra-infralimbic Apomorphine Microinjection
چکیده انگلیسی مقاله Objective(s): The dopamine level of the nucleus accumbens changes during some stereotyped behaviors. To study dopamine level of the nucleus accumbens in intra infralimbic apomorphine-induced climbing, microdialysis probes were implanted into the nucleus accumbens shell of male Sprague Dawley rats weighting 275–400 g. Materials and Methods: The rats were divided into two groups (apomorphine and control) of least eleven rats in each group. Apomorphine at dose of 5 μg/0.5 μl or its vehicle was microinjected into the infralimbic in apomorphine and control groups respectively. Then, changes in dopamine levels in the nucleus accumbens shell were monitored. The concentration of dopamine was measured by High-Performance Liquid Chromatography-Electochemical (HPLC-ECD). Finally, the stereotyped behaviors were recorded. Results: The mean of dopamine levels for all of after microinjection period in control and drug groups were 450% and 150% respectively compared to those of before microinjection period. However, there was no significant difference between groups of apomorphine and control. In addition, the return of dopamine level to the baseline was faster in apomorphine group than the control group. Conclusion: The intra infralimbic apomorphine -induced climbing at dose of 5 μg/0.5 μl was not modulated via the increase of dopamine level in the nucleus accumbens area.
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نویسندگان مقاله عباس علیمرادیان | abbas alimoradian
department of pharmacology, school of medicine, arak university of medical sciences, arak, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

جواد ساجدیان فرد | javad sajedianfard
department of physiology, school of veterinary medicine, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

فایقه بهای الدینی بیگی | faegheh baha aldini beigy
department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran; e-mail bzarandi@hotmail.com

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمدرضا پنجه شاهین | mohammad reza panjehshahin
natural amp;amp; medicinal chemistry research center and department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

علی اکبر اوجی | ali akbar owji
department of biochemistry, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_989.html
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