این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۵، صفحات ۷۰۵-۷۰۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Development of 177Lu-phytate Complex for Radiosynovectomy
چکیده انگلیسی مقاله Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and checked using ITLC (MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100 µCi/100 µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>99.9 %). Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology
کلیدواژه‌های انگلیسی مقاله Biodistribution Lutetium-177 Phytate Radiosynovectomy
نویسندگان مقاله حسن یوسف نیا | hassan yousefnia
radiopharmaceutical research and development lab, nuclear science and technology research institute nstri , tehran, iran, p.o.box 14395-836 2 faculty of energy engineering and physics, amirkabir university of technology. tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی امیرکبیر (Amirkabir university of technology)

امیررضا جلیلیان | amir reza jalilian
radiopharmaceutical research and development lab, nuclear science and technology research institute nstri , tehran, iran, p.o.box 14395-836


علی بهرامی سامانی | ali bahrami samani
radiopharmaceutical research and development lab, nuclear science and technology research institute nstri , tehran, iran, p.o.box 14395-836


محمد مزیدی | mohammad mazidi
radiopharmaceutical research and development lab, nuclear science and technology research institute nstri , tehran, iran, p.o.box 14395-836


محمد قنادی مراغه | mohammad ghannadi maragheh
radiopharmaceutical research and development lab, nuclear science and technology research institute nstri , tehran, iran, p.o.box 14395-836


فریدون عباسی دوانی | fereydoun abbasi davani
radiation application group, faculty of nuclear engineering, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_784.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات