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Iranian Journal of Basic Medical Sciences، جلد ۱۵، شماره ۶، صفحات ۱۱۶۲-۱۱۶۷
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چکیده فارسی مقاله
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عنوان انگلیسی Evaluation of Curcumin Effects on Post-Operative Peritoneal Adhesion in Rats
چکیده انگلیسی مقاله Objective(s)The purpose of this study holds, for the first time, an evaluation of the intraperitoneal curcumin lavage on the development of post-operative intra-abdominal adhesions.Materials and MethodsThirty male Wistar rats were randomized into five groups. The rats were administered anesthesia and underwent surgery in order to create intra-abdominal adhesions. Before the abdomen was closed, five lavage solutions of normal saline (control group), curcumin 1, 3, and 5% and hydrocortisone 1% were used for 1 min. After five days, the rats underwent laparatomy. Based on a histopathology evaluation and serum levels of hs-CRP, TNFα and Isoprostane, peritoneal adhesion severity were compared in different groups.ResultsThe groups that received curcumin 3% and 5% showed a significant decrease in TNFα, hs-CRP and Isoprostane serum concentrations compared to the normal saline group, however, these differences were not significant, between the other groups. The intensity of adhesions in the different groups of curcumin 1, 3 and 5% concentrations and hydrocortisone 1% were compared to the normal saline control group and no significant statistical difference was recorded.ConclusionCurcumin was not effective in post-operative peritoneal adhesion; however, further studies on curcumin lavage in higher concentrations are recommended.
کلیدواژه‌های انگلیسی مقاله Curcumin, Post-operative Peritoneal Adhesion, Rat
نویسندگان مقاله وحید jomezadeh | vahid jomezadeh
department of surgery, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امیرهوشنگ محمدپور | amir hooshang mohammadpour
pharmaceutical research centre, mashhad university of medical science, mashhad, iran|department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امید رجبی | omid rajabi
department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا توسلی | alireza tavassoli
department of surgery, faculty of medicine, mashhad university of medical sciences, mashhad, iran|endoscopic amp;amp;minimally invasive surgery research centre, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

قدرت اله مداح | ghodratolah maddah
department of surgery, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_4935.html
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