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Iranian Journal of Basic Medical Sciences، جلد ۱۵، شماره ۳، صفحات ۸۵۳-۸۵۹
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کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Teratogenic Effects of Sulfur Mustard on Mice Fetuses
چکیده انگلیسی مقاله Sulfur Mustard (SM) has been used as a chemical warfare agent, in the World War I and more recently during Iraq-Iran war in early 1980s’. Its biological poisoning effect could be local or systemic and its effect depends on environmental conditions, exposed organs, and the extent and duration of exposure. It is considered as a strong alkylating agent with known mutagenic, carcinogenic effects; although a few studies have been performed on its teratogenicity so far. Materials and Methods Mice were administered with SM intraperitoneally with a dose of 0.75 and 1.5 mg/kg in different periods of their gestation (gestational age of 11, 13 and 14 weeks). Control mice groups were included. Between 5 and 9 mice were used in each group. Dams underwent cesarean section on day 19 of their gestation. External examination was performed on the animals investigating craniofacial and septal defects and limb malformations such as adactyly and syndactyly. All data were analyzed by Chi-Square test and Fisher's exact test. The P- value less than 0.05 was considered significant. Results Craniofacial and septal defects as well as the limb malformations were the most common types of birth defects, displaying an extremely complex biomedical problem. Conclusion This study confirms a significant correlation between SM exposure and its teratogenic effect. We postulated that the malformations could be caused by an uncontrolled migration of neural crest cells, causing developmental disorders. In addition to environmental factors, modifying genes could play an important role in the pathogenesis of the defects.
کلیدواژه‌های انگلیسی مقاله Malformation, Sulfur mustard, Teratogenicity
نویسندگان مقاله نسرین sanjarmoosavi | nasrin sanjarmoosavi
department of medical genetics, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ناصر sanjarmoosavi | naser sanjarmoosavi
department of medical genetics, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مرضیه شاهسون | marziyeh shahsavan
department of basic sciences, mashhad azad university, mashhad, iran


محمد حسن زاده nazarabadi | mohammad hassanzadeh nazarabadi
department of medical genetics, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_4870.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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