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Iranian Journal of Basic Medical Sciences، جلد ۱۵، شماره ۲، صفحات ۷۰۲-۷۰۸
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عنوان انگلیسی Relationship between Patient Demographic Characteristics, Valproic Acid Dosage and Clearance in Adult Iranian Patients
چکیده انگلیسی مقاله Objective(s) As there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (VPA), this study was conducted to investigate the relationship between patient demographic characteristics, VPA dosage and the drug clearance in adult Iranian patients. Materials and Methods Patients (N= 47) were either on monotherapy with VPA or were under co-treatment with drugs that have no effect on VPA pharmacokinetic (PK) profile. All of the patients received VPA at therapeutic dose. Steady state trough plasma concentrations of VPA were determined by Fluorescence Polarization Immunoassay (FPIA) and VPA apparent clearance (CL/F) were calculated in each patient. Results Mean VPA dose and VPA CL/F were 8.93±2.2 mg/kg/day and 0.65±0.55 l/hr respectively. No significant correlations were found between VPA CL/F and patients' age, TBW and VPA dose. VPA CL/F values of male and female patients were compared and no significant difference between these two groups was noted (P> 0.05). Significant correlation between VPA dose and total trough plasma concentration was found (P= 0.001). Mean total VPA plasma concentration was 54.51±23.74 mg/l. Conclusion Our study showed PK of VPA was not affected by age, sex, TBW and VPA dose. However, for detailed results and construction of VPA PK model in Iranian patients, it is necessary to evaluate VPA PK in a larger sample size with different VPA doses, age and TBW ranges. 
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نویسندگان مقاله تامارا عاقبتی | tamara aghebati
pharmaceutical research centre, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محسن فروغی پور | mohsen foroughipour
department of neurology, faculty of medicine, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمودرضا آذرپژوه | mahmoud reza azarpazhooh
department of neurology, faculty of medicine, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نغمه مخبر | naghme mokhber
department of psychiatry, faculty of medicine amp;amp; psychiatric research centre, ebn-sina hospital, mashad university of medical sciences, mashhad, iran


محمد حسن زاده خیاط | mohammad hasanzadeh khayat
pharmaceutical research centre, mashhad university of medical sciences, mashhad, iran|department of medicinal chemistry, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ناصر وحدتی | naser vahdati
department of pharmacodinamy amp;amp; toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امیرهوشنگ محمدپور | amir hooshang mohammadpour
pharmaceutical research centre, mashhad university of medical sciences, mashhad, iran|department of pharmacodinamy amp;amp; toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_4841.html
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