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Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۵، صفحات ۴۲۲-۴۲۷
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عنوان انگلیسی Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica
چکیده انگلیسی مقاله Objective(s) Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their anti­inflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.
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نویسندگان مقاله jessy الیزابت ماتیو | jessy elizabeth mathew
department of pharmaceutical chemistry, mcops, manipal university, karnataka, india


srinivasan keloth kaitheri | srinivasan keloth kaitheri
department of pharmaceutical chemistry, mcops, manipal university, karnataka, india


seekarajapuram dinakaranvachala | seekarajapuram dinakaranvachala
department of pharmaceutical chemistry, mcops, manipal university, karnataka, india


magi خوزه | magi jose
department of pharmaceutical chemistry, mcops, manipal university, karnataka, india|department of oral pathology, yenepoya university, mangalore, karnataka, india
نشانی اینترنتی http://ijbms.mums.ac.ir/article_5037.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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