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Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۳، صفحات ۲۶۴-۲۷۴
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عنوان انگلیسی Protective Effect of Diosgenin and Exercise Training on Biochemical and ECG Alteration in Isoproterenol- Induced Myocardial Infarction in Rats
چکیده انگلیسی مقاله Objective(s) Several studies have reported improved response of exercised hearts to myocardial infarction (MI). This study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), lipids, and electrocardiographic (ECG) patterns in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Materials and Methods One hundred Wistar rats were divided into ten groups: Control rats (C), saline (S), L-cremephor (LC), exercise (E), diosgenin dissolved in L-cremephor (15 mg/kg/day) (D), exercise+ diosgenin (E+D), ISO injected (150 mg/kg) (ISO), exercise + ISO (E+ISO), diosgenin + ISO (D+ISO) and exercise+ diosgenin+ ISO (E+D+ISO). At the end of the experiment all animals anesthetized and blood samples were collected for biochemical estimation and also the ECG patterns were recorded. Results Exercise and diosgenin pretreatment significantly decreased the lactate dehydrogenase (LDH) and TBARS level in ISO injected animals. Exercise and diosgenin pretreatment significantly decreased serum total cholesterol and increased high density lipoprotein (HDL-C). ISO-treated rats showed pathological Q waves along with elevated ST segments. The altered electrocardiograms (ECG) of ISO-treated rats were also restored to near normal by diosgenin and exercise, but exercise and diosgenin had synergistic effects. Conclusion The present investigation demonstrates that combination of diosgenin and exercise exhibited significant protection against ISO induced electrocardiographical and biochemical changes. The cadioprotective mechanism(s) appear to be through changing lipid metabolism.
کلیدواژه‌های انگلیسی مقاله Diosgenin, Isoproterenol, Myocardial Infarction, Treadmill
نویسندگان مقاله افشین سلیمه | afshin salimeh
department of physiology, drug applied research center, tabriz university of medical sciences,tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

مصطفی محمدی | mustafa mohammadi
department of physiology, drug applied research center, tabriz university of medical sciences,tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

گیسو محدث | gisou mohaddes
department of physiology, drug applied research center, tabriz university of medical sciences,tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

رضا بدل زاده | reza badalzadeh
department of physiology, drug applied research center, tabriz university of medical sciences,tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_5004.html
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