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Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۱، صفحات ۶۷-۷۴
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Effect of Matricaria aurea (Loefl.) Shultz-Bip. Hydroalcoholic Extract on Acetic Acid-Induced Acute Colitis in Rats
چکیده انگلیسی مقاله Objective(s) Matricaria aurea is found abundant in Iran and has large similarities in constituents especially essential oils, flavones and flavonoides as well as traditional uses to the main species; Matricaria recutita L. Anti-inflammatory, antioxidant and spasmolytic properties of the main species suggest that this plant may have beneficial effects on inflammatory bowel diseases so the present study was carried out. Materials and Methods Hydroalcoholic extract of plant with doses of 200, 400, 800 mg/kg were administered orally (p.o.) for 5 days and rectally (i.r.) (400 and 800 mg/kg) at 15 and 2 hr before ulcer induction. To induce colitis, 2 ml of acetic acid 4% was instilled intra-colonically to separate groups of male Wistar rats (n= 6). Normal saline (2 ml), prednisolone (4 mg/kg) and hydrocortisone acetate (20 mg/kg) enema were administered to control and reference groups respectively. The tissue injures were assessed macroscopically and histopathologically. Results Greater doses of extract (400 and 800 mg/kg) reduced colon weight/length ratio (P< 0.01) and the highest test dose (800 mg/kg p.o. or i.r.) was effective to decrease tissue damage parameters including ulcer severity, area and index (P< 0.01) as well as inflammation severity and extent, crypt damage and total colitis index (P< 0.01) significantly. Conclusion It is concluded that Matricaria aurea extract was effective to protect against acute colitis in acetic acid model and this effect was more significant with the greater doses administered orally or rectally. Further studies are warranted to ascertain the mechanisms that are involved and the responsible active constituents.
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نویسندگان مقاله محسن میناییان | mohsen minaiyan
department of pharmacology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نصراله قاسمی دهکردی | nasrollah ghassemi dehkordi
department of pharmacognosy, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پروین محزونی | parvin mahzouni
department of clinical pathology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

میثم انصاری roknabady | meysam ansari roknabady


نشانی اینترنتی http://ijbms.mums.ac.ir/article_4966.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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