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Iranian Journal of Basic Medical Sciences، جلد ۱۳، شماره ۳، صفحات ۱۱۹-۱۲۵
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عنوان انگلیسی Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats
چکیده انگلیسی مقاله Objective(s) Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats. Materials and Methods For evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests. Results The extract of T. chamaedrys (50-200 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant (P< 0.01) inhibition of the second phase response in the formalin pain model, while only the high dose (200 mg/kg) of the extract showed an analgesic effect in the first phase. The extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. The tail flick latency was dose dependently enhanced by the extract but this was significantly (P< 0.05) lower than that produced by morphine (10 mg/kg). The extract (25-250 mg/kg) administered 1 hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. No effect was observed with the dextran-induced oedema model. Results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract. Conclusion The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. The role of alkaloids, flavonoids and triterpenoids will evaluate in future studies.
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نویسندگان مقاله علی پورمتعبد | ali pourmotabbed
department of physiology, school of medicine, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

امیر فرشچی | amir farshchi
department of physiology, school of medicine, kermanshah university of medical sciences, kermanshah, iran|department of pharmacoeconomy and pharmaceutical management, school of pharmacy, tehran university of medical sciences, tehran, iran|student scientific research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

گلبرگ غیاثی | golbarg ghiasi
department of physiology, school of medicine, kermanshah university of medical sciences, kermanshah, iran|department of pharmacoeconomy and pharmaceutical management, school of pharmacy, tehran university of medical sciences, tehran, iran|student scientific research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

پیمان ملک خطابی | peyman malek khatabi
razi herbal medicines research center, lorestan university of medical sciences, khoramabad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی لرستان (Lorestan university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_5097.html
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