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Iranian Journal of Basic Medical Sciences، جلد ۱۳، شماره ۱، صفحات ۱۹۵-۲۰۱
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عنوان انگلیسی Synthesis and Effects of Novel Dihydropyridines as Dual Calcium Channel Blocker and Angiotensin Antagonist on Isolated Rat Aorta
چکیده انگلیسی مقاله Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and 5b were evaluated by cumulative addition of these drugs to the bath solution. Results The results showed that compounds 5a and 5b have both L-type calcium channel and AT' receptor blocking activity. Their effects on AT' receptors are 1000 and 100,000 times more than losartan respectively. The activity of compound 5b on L-type calcium channel is significantly less than nifedipine but compound 5a has comparable effect with nifedipine. Conclusion Finally we concluded that these two new Compounds can be potential candidates to be used as effective antihypertensive agents.
کلیدواژه‌های انگلیسی مقاله Angiotensin, Aorta, Dihydropyridine
نویسندگان مقاله فرزین هادی زاده | farzin hadizadeh
school of pharmacy, mashhad university of medical sciences, mashhad, iran|biotechnology research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محسن ایمن شهیدی | mohsen imenshahidi
school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

پیمان اسماعیلی | payman esmaili
biotechnology research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مرتضی تقی آبادی | morteza taghiabadi
school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_5063.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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