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Iranian Journal of Basic Medical Sciences، جلد ۱۲، شماره ۲، صفحات ۱۱۲-۱۲۰
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عنوان انگلیسی Qualitative and Quantitative Analysis of the Effects of Quinazolinones on Internal Organs of Newborn Balb/C Mice
چکیده انگلیسی مقاله Objective(s) Quinazolinones are heterocyclic compounds, with biological and pharmacological activities, such as inhibiting some proteins, enzymes and reducing blood lipids. Materials and Methods Following previous results of our group, effects of two new derivatives of quinazolinones 9(3)-quinazolinone-2-propyl-2-phenylethyl (QPPE) and 9(3)-quinazolinone-2-ethyl-2-phenylethyl (QEPE) on livers, intestines and kidneys of newborn Balb/C mice were investigated. Pregnant mice were divided into four groups of control, sham, experimental 1, treated with QPPE, and experimental 2, treated with QEPE. Experimental groups received 100 mg/kg body weight (most effective dose) of QPPE and QEPE, sham groups received methyl cellulose 0.05% (the solvent) and control groups received distilled water, intraperitoneally (IP), on day 8 of gestation. Five days after birth, livers, intestines and kidneys were removed, fixed in formalin 10%, stained with hematoxylene and eosin for histological and pathological studies. Results Results showed appearance of fatty changes in livers, an increase in diameters of hepatocytes and central veins of livers, and reduction in the lengths of villi of proximal, middle and distal segments of newborn Balb/C mice intestines. Furthermore, there was a diminished diameter of the lumen of the proximal tubules, and average diameter of the lumen of distal tubules which led to an increase in the number of glomeruli cells of newborn Balb/C mice kidneys. Conclusion Regarding inflammation in different parts of the kidneys, livers and intestines, our investigations suggest that quinazolinones may have some toxic effects on embryos.
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نویسندگان مقاله مریم شمس لاهیجانی | maryam shams lahijani
developmental biology,animal sciences, faculty of biological sciences, shahid-beheshti university sbu ,g.c., tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

هدی رجبی | hoda rajabi
developmental biology,animal sciences, faculty of biological sciences, shahid-beheshti university sbu ,g.c., tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

ثمر اعتماد | samar etemad
developmental biology,animal sciences, faculty of biological sciences, shahid-beheshti university sbu ,g.c., tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

مهلا فدوی اسلام | mahla fadavi eslam
developmental biology,animal sciences, faculty of biological sciences, shahid-beheshti university sbu ,g.c., tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_5154.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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