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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۳، شماره ۵۵، صفحات ۵۸-۶۵
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عنوان انگلیسی Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer
چکیده انگلیسی مقاله Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat. Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index. Results: All doses of the A. vera leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (p < 0.05). Conclusion: These plants have protective effect against NSAID-induced gastric ulcer in the rat. The A. vera leaf gel seems noticeably more effective than the other 3 plants in this respect.
کلیدواژه‌های انگلیسی مقاله Anti-ulcer, Non-steroidal anti-inflammatory drug, Rat
نویسندگان مقاله h فلاح حسینی | h fallah huseini
medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

s کیان بخت | s kianbakht
medicinal plants research center, institute of medicinal plants, acecr, karaj, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

t رجبیان | t radjabian
department of biology, faculty of science, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-71-22&slc_lang=en&sid=fa
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