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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۳، شماره ۵۱، صفحات ۶۲-۷۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Rubia tinctorum L. Extractson Carrageenan-Induced Paw Edema in Rats
چکیده انگلیسی مقاله Background: Inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. Herbs have been traditionally used as anti-inflammatory agents since very early times. Rubia tinctorum L. is one of these herbs that havebeen used for treating inflammatory diseases in Iranian traditional medicine. Objective: This study aims at considering anti-inflammatory effects of R. tinctorum and comparing its extracts in this property. Methods: The root of Rubia tinctorum (Rubiaceae) was collected from Yazd province, in the center of Iran. The root extracts of plant were studied for their anti-inflammatory activity by using carrageenan-induced hind paw edema in Wistarmale rats. Indomethacin and normal saline were used as positive and negative controls, respectively. Different concentrations of aqueous, ethanolic, and 50% aq. ethanolic extracts (600, 800, 1000 mg/kg) were given orally before carrageenan injection. The paw thickness was measured at 1, 3 and 5 hours after injection. Results: Both, aqueous and 50% eq. ethanolic extracts reduced paw edema at 600 and 800 mg/kg concentrations. Moreover, ethanolic extract showed significant effect only in1sthour after carrageenan injection. Conclusion: The results indicated that the aqueous extract were exhibited higher anti-inflammatory effect compared with other extracts. Accordingly, the potent anti-inflammatory effect of the root extracts is attributed to the polar compounds which are extracted in the water.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله m شریف زاده | m sharifzadeh
1- department of pharmacology and toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n عبادی | n ebadi
2- department of traditional pharmacy, faculty of traditional medicine andpersian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a منایی | a manayi
4- medicinal plants research center, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m کمالی نژاد | m kamalinejad
5- department of pharmacognosy, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

h رضایی زاده | h rezaeizadeh
6- student scientific research center, faculty of traditional medicine, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m میراب زاده | m mirabzadeh
2- department of traditional pharmacy, faculty of traditional medicine andpersian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b بنکدار یزدی | b bonakdar yazdi
1- department of pharmacology and toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m خانوی | m khanavi
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran. tel amp;amp; fax 98-21-66954706

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-149-6&slc_lang=en&sid=fa
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده پژوهشی
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