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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۳، شماره ۳۹، صفحات ۷۶-۸۱
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عنوان انگلیسی Effect of Ethanolic Extract of Mespilus germanica on Cutaneous Leishmaniasis in BALB/c Mice
چکیده انگلیسی مقاله Background: Leishmaniasis is a vector-borne disease caused by flagellated protozoan parasites of the genus Leishmania, which affects both humans and other mammals. Most of the available drugs against the disease are toxic and some are parasite resistance to them. Objective: The purpose of this study was to examine the effect of Mespilus germanica extract on cutaneous leishmaniasis (CL) in BALB/c Mice. Methods: Ethanolic extract of Mespilus germanica with 40, 60 and 80% concentrations were prepared. Then, the BALB/c mice were inoculated subcutaneously by 0.1 ml liquid phase culture containing promastigotes of Leishmania major. Ethanolic extract of the leaves of Mespilus germanica in different concentrations, were used topically on CL lesions. Results: The mean diameter of the lesions were decreased, and also the number of parasites in the lesions had declined with complete healing by ending the period time of treatment in 4 mice (26.7%), (p< 0.05) and in 9 animals (82%), (p< 0.05) respectively, by using the 40% concentration of the extract. Also in a concentration of 60%, mean ulcer diameter decreased, with complete healing in 3 mice (20%), (p< 0.001). In this concentration, the mean number of parasites in lesions had declined (66.4%), with total elimination in 8 animals (p< 0.001). Conclusion: We showed that the extract of Mespilus germanica has the highest effectiveness in concentration of 40%, causing greater reductions in both ulcer diameter and the number of parasites in the lesions compared with other prepared concentrations. Therefore, we suggest the use of 40% extract for the treatment of human cases.
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نویسندگان مقاله n شریعتی فر | n shariatifar
food and drug deputy, university of medical sciences, tehran, iran, enghelab avenue, ghods street, p.o.box 14155-6453, tehran, iran tel amp;amp; fax 98 – 21 – 66466062


r رحیم نیا | r rahimnia
graduate, college of medical, tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

am جمشیدی | am jamshidi
food and drug deputy, ministry of health and medical education

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

m پیرعلی همدانی | m pirali hamedani
medicinal chemistry department, college of pharmacy, tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

sh شعیبی | sh shoeibi
food and drug laboratory research center fdlrc , ministry of health moh
نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-147-2&slc_lang=fa&sid=fa
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده کنترل غذا و دارو
نوع مقاله منتشر شده پژوهشی
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