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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۳، شماره ۳۱، صفحات ۱۱۸-۱۲۴
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عنوان انگلیسی Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat
چکیده انگلیسی مقاله Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and ginger (G) group that received 100mg/kg-perday (oral), (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus ginger 100mg/kg-perday (G), daily for, 4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC, MDA and sperm parameters and testis tissues of Rat in whole groups were removed then prepared for analyzes. Results:TAC, MDA and sperm parameters significantly decreased in diabetic group.treatment groub that has received Ginger 100 mg/kg (oral) show increasing in TAC and sperm parameters (p< 0.05) in comparison to experimental groups (p< 0.05). Conclusion: Since in our study 100 mg/kg (oral) ginger have significantly Preventive effect on sperm parameters, so it seems that using it can be effective for treatment in Diabetic Rat.
کلیدواژه‌های انگلیسی مقاله Diabetic, Ginger rhizome, Streptozotocin, Sperm, Rat
نویسندگان مقاله m نصیری | m nassiri
department of veterinary pathology, islamic azad university urumia branch

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

a خاکی | a khaki
department of veterinary pathology yrc , islamic azad university tabriz branch

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

hr احمدی آشتیانی | hr ahmadi ashtiani
department of clinical biochemistry, school of medical science, tarbiat modarres university, tehran, iran; biochemistry amp;amp; nutrition department of zanjan medical university

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

sh رضازاده | sh rezazadeh
institute of medicinal plants, complex of academic center for educational and cultural research acecr , kavosh boulevard, supa boulevard, 55th kilometer of tehran-gazvin freeway, pouleh kordan, karaj, iran tel 98-261-4764010 – 19, fax 98-261-476402

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

h رستگار | h rastgar
ministry of health and medical education, food amp;amp; drug laboratory research center,

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

sh gharachurlu | sh gharachurlu
department of veterinary pathology yrc , islamic azad university tabriz branch

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-186-4&slc_lang=en&sid=fa
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