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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۵۳، صفحات ۶۹-۸۱
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عنوان انگلیسی Antibacterial and Wound Healing Properties of Thymol (Thymus vulgaris Oil) and its Application in a Novel Wound Dressing
چکیده انگلیسی مقاله Background: In developing new products for skin care and wound treatment, biocompatibility plays a major role in the choice of ingredients. Thymol, an essential oil extracted from thyme plant, exhibits outstanding antibacterial properties, but more importantly, it proves to be much more compatible to skin cells in comparison to some conventionally used antibiotic drugs and chemicals. Objective: The aim of the study was the use of thymol as an antibacterial and wound healing promoting agent in development of a novel wound dressing. Methods: The antibacterial properties of thymol before and after application in the dressing were analyzed by MIC and Disk Diffusion methods respectively. To ensure biocompatibility, MTT assay was used to assess the effect of thymol on skin fibroblast cells. In addition, effects of thymol on dressing’s structure and its mechanical properties were studied by SEM and tensile strength tests respectively. Results: MIC investigation showed that thymol is capable of halting bacterial growth in concentrations as low as 156ppmdepending on the bacterial strain. Assessment of the product containing thymol by Disk diffusion method proved that the essential oil would retain its effectiveness when incorporated in the final product. Investigation of thymol’s biocompatibility by MTT assay resulted in a rather unexpected outcome, thymol increased fibroblast cell growth significantly, but the exact amount could not be calculated due thymol’s interference with the test material (MTT). Furthermore, increasing the concentration of thymol in the dressing increased its porosity and elongation on stress, but reduced its pore size and maximum stress. Conclusion: The observed data backed the original claim of antibacterial and wound healing properties, but also showed that incorporating thymol into the dressing increases its elasticity and porosity, but reduces its mechanical strength.
کلیدواژه‌های انگلیسی مقاله Antibacterial, Thymol, Wound dressing, Wound healing
نویسندگان مقاله p mollarafie | p mollarafie
school of chemical engineering, college of engineering, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

p خدیوپارسی | p khadiv parsi
school of chemical engineering, college of engineering, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

r ضرغامی | r zarghami
school of chemical engineering, college of engineering, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

m امینی فضل | m amini fazl
department of applied chemistry, faculty of chemistry, university of tabriz, tabriz, iran

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

r غفارزادگان | r ghafarzadegan
medicinal plants research center, institute of medicinal plants, acecr, p.o.box mehr villa 31375-369, karaj, iran tel 98 - 26 - 34764010-9, fax 98 - 26 34764021

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-218-3&slc_lang=en&sid=fa
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