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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۲۹، صفحات ۳۹-۴۴
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عنوان انگلیسی Taxane Diterpenoids from Taxus baccata L. Growing in Iran
چکیده انگلیسی مقاله Background: There are eight Taxus species and two hybrids in the world and Taxus baccata L. (European yew) is the single representative in Iran. Until now, a large number of taxoids possessing different skeleton systems, as well as lignans, flavonoids, steroids and sugar derivatives have been isolated from various Taxus species. Taxoids are highly oxygenated diterpenes isolated from different species of yew trees (family Taxaceae). They have received considerable attention after the discovery of the clinical efficacy of paclitaxel against different cancers due to its remarkable inhibition of microtubules polymerization leading to apoptosis of cancer cells. Objective: This study was conducted for extraction, purification and identification of taxoids occurring in the aerial parts of Taxus baccata L. growing in Iran. Methods: The plant materials were extracted with organic solvent and after defatting, partitioning, column chromatography and thin layer chromatography steps, the obtained compounds were characterized on the basis of spectral data. Results: Two taxane diterpenoids were isolated. The structures of these taxoids were established as 5-Cinnamoyl-10-acetyltaxicin-I and 2-Deacetyltaxinine E on the basis of spectral analysis. Conclusion : These two taxoids were not previously encountered in Taxus baccata L. species.
کلیدواژه‌های انگلیسی مقاله Taxus baccata L., Isolation, Taxoids, Taxaceae
نویسندگان مقاله a حاجی آخوندی | a hadjiakhoondi
department of pharmacognosy, medicinal plants research center, faculty of pharmacy, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m پیرعلی همدانی | m pirali hamedani
department of medicinal chemistry, faculty of pharmacy, tehran university of medical sciences, tehran, iran, tel 98-21-66959090, fax 98-21-66461178

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

mr وردیان ریزی | mr verdian rizi
department of pharmacognosy, medicinal plants research center, faculty of pharmacy, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

sh رضازاده | sh rezazadeh
department of pharmacognosy and pharmaceutics, institute of medicinal plants, acecr, tehran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-241-6&slc_lang=en&sid=fa
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زبان مقاله منتشر شده en
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