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Iranian Journal of Microbiology، جلد ۸، شماره ۳، صفحات ۱۶۱-۱۶۷
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عنوان انگلیسی Frequency of genes encoding erythromycin ribosomal methylases among Staphylococcus aureus clinical isolates with different D-phenotypes in Tehran, Iran
چکیده انگلیسی مقاله Background and Objectives: Macrolide, lincosamide and streptogramin type B (MLSB) antibiotics are important in the treatment of Staphylococcus aureus infections and existence of isolates with ability to resist against MLSB antibiotics is worrisome. Materials and Methods: In this cross sectional study, 101 S. aureus isolates were collected from patients of five selected hospitals in Tehran over a period of five months. Disk diffusion tests and differentiation between constitutive and inducible resistances were carried out by D-test. The presence of mecA, msrA, ermA and ermC genes were detected using PCR or multiplex PCR. Results: Out of 101 S. aureus isolates, 58 (57.4%) were methicillin resistant and 57 (56.4%) expressed resistance to erythromycin. The prevalence of constitutive MLSB (cMLSB), inducible MLSB (iMLSB) and MS (Negative) phenotype in all erythromycin resistant isolates were 71.9, 26.3 and 1.7%, respectively. Out of all the erythromycin resistant isolates, 57.8% harbored both ermA and ermC genes which possessed constitutive resistance. 8.7% of the isolates contained ermA gene alone which possessed inducible resistance with D phenotype and 5.2% of isolates just contained ermC gene which had inducible resistance with D+ phenotype. msrA gene was detected in 3.5% of the erythromycin resistant S. aureus isolates with constitutive resistance. None of the genes were detected among MS phenotypes. Conclusion: In this study, most of S. aureus isolates carried both ermA and ermC genes and there was a significant relationship ( P value ≤ 0.05) between different resistance phenotypes and erm genes. Keywords: Staphylococcus aureus , D-test, Erm A, ErmC, MsrA
کلیدواژه‌های انگلیسی مقاله Staphylococcus aureus,D-test,Erm A,ErmC,MsrA
نویسندگان مقاله ساره سادات حسینی | sareh sadat hosseini
department of microbiology, school of medicine, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

محمد نیاکان | mohammad niakan
department of microbiology, school of medicine, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

حوریه صادری | horieh saderi
molecular microbiology research center, school of medicine, shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

میترا مطلبی | mitra motallebi
department of microbiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مروت طاهری کلانی | morovat taherikalani
razi herbal medicines research center amp;amp; department of microbiology, school of medicine, lorestan university of medical sciences, ilam, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی لرستان (Lorestan university of medical sciences)

خیرالله اسداللهی | khairollah asadollahi
department of social medicine, school of medicine, ilam university of medical sciences, ilam, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)

محمد ایمان عینی | mohammad emaneini
department of microbiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/884
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