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Iranian Journal of Microbiology، جلد ۸، شماره ۲، صفحات ۹۳-۱۰۰
عنوان فارسی
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عنوان انگلیسی Evaluation of antibacterial efficiency of chitosan and chitosan nanoparti- cles on cariogenic streptococci: an in vitro study
چکیده انگلیسی مقاله Background and Objectives: The most prevalent and worldwide oral disease is dental caries that affects a significant pro- portion of the world population. There are some classical approaches for control, prevention and treatment of this pathologic condition; however, the results are still not completely successful. Therefore new methods are needed for better management of this important challenge. Chitosan is a natural and non-toxic polysaccharide with many biological applications, particu- larly as an antimicrobial agent. Chitosan nanoparticle is a bioactive and environment friendly material with unique physico- chemical properties. The aim of the present study was to investigate the antimicrobial effect of chitosan and nano-chitosan on the most important cariogenic streptococci. Materials and Methods: For evaluation of antimicrobial effect of chitosan and nano-chitosan against oral streptococci broth micro-dilution method was carried out for four bacterial species; Streptococcus mutans, Streptococcus sobrinus, Streptococ- cus sanguis and Streptococcus salivarius. Also the effect of these materials on adhesion of above bacteria was evaluated. One-way ANOVA and post hoc Tukey test were used for statistical analysis. Results: The MICs of chitosan for S. mutans, S. sanguis, S. salivarius and S. sobrinus were 1.25, 1.25, 0.625 and 0.625 mg/ mL, respectively. The MIC of chitosan nanoparticle for S. mutans, S. salivarius and S. sobrinus was 0.625 mg/mL and for S. sanguis was 0.312 mg/mL. Chitosan and chitosan nanoparticles at a concentration of 5 mg/mL also reduced biofilm forma- tion of S. mutans up to 92.5% and 93.4%, respectively. Conclusion: T e results of this study supported the use of chitosan and chitosan nanoparticles as antimicrobial agents against cariogenic Streptococci.
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نویسندگان مقاله اعظم علی اصغری | azam aliasghari
department of biology, faculty of sciences, university of isfahan, iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

محمد ربانی خوراسگانی | mohammad rabbani khorasgani
department of biology, faculty of sciences, university of isfahan, iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

صدیقه واعظی فر | sedigheh vaezifar
department of medical engineering, payame noor university, iran.

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

فاتح رحیمی | fateh rahimi
department of biology, faculty of sciences, university of isfahan, iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

حبیب الله یونسی | habibollah younesi
department of environmental science, faculty of natural resources, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مریم خروشی | maryam khoroushi
dental materials research center amp;amp; department of operative dentistry, school of dentistry, isfahan university of medical sciences isfahan , iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/788
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