این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Microbiology، جلد ۷، شماره ۴، صفحات ۲۱۴-۲۲۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evolution of hepatitis B virus surface gene and protein among Iranian chronic carriers from different provinces
چکیده انگلیسی مقاله Background and Objectives: Iranian chronic HBV carrier’s population has shown a unique pattern of genotype D distri- bution all around the country. The aim of this study was to explore more details of evolutionary history of carriers based on structural surface proteins from different provinces. Materials and Methods: Sera obtained from 360 isolates from 12 Different regions of country were used for amplificationand sequencing of surface proteins. A detailed mutational analysis was undertaken. Results: The total ratio for Missense/Silent nucleotide substitutions was 0.96. Sistan and Kermanshah showed the lowest rate of evolution between provinces (P = 0.055). On the other hand, Khorasan Razavi and Khoozestan contained the highest ratio (P = 0.055). The rest of regions were laid between these two extremes. Azarbayjan and Guilan showed the highest proportion of immune epitope distribution (91.3% and 96%, respectively). Conversely, Sistan and Tehran harbored the least percentage (66.6% and 68.8%, respectively). Kermanshah province contained only 5.2%, whereas Isfahan had 54.5% of B cell epitope distribution. In terms of T helper epitopes, all provinces showed a somehow homogeneity: 22.58% (Fars) to 46.6% (Khuz- estan). On the other hand, distribution of substitutions within the CTL epitopes showed a wide range of variation between 6.6% (Khuzestan) and 63% (Kermanshah). Conclusion: Further to low selection pressure found in Iranian population, the variations between different regions designate random genetic drift within the surface proteins. These finding would have some applications in terms of specific antiviral regimen, design of more efficient vaccine and public health issues.
کلیدواژه‌های انگلیسی مقاله Hepatitis B,Surface Proteins,HBsAg
نویسندگان مقاله فاطمه رمضانی | fatemeh ramezani
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


سیدموید علویان | seyedmoayed alavian
middle east liver diseases center meld centers , tehran, iran.


احمدرضا صادقی | ahmadreza sadeghi
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


ابوالفضل khedive | abolfazl khedive
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


لیلا قالیچی | leila ghalichi
mental health research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مهدی نوروزی | mehdi norouzi
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


هادی کریم زاده | hadi karimzadeh
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


رضا ملک زاده | reza malekzadeh
digestive disease research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

قدرت منتظری | ghodrat montazeri
digestive disease research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عظیم نجاتی زاده | azim nejatizadeh
research center for molecular medicine, hormozgan university of medical sciences, bandar abbas, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی هرمزگان (Hormozgan university of medical sciences)

مسعود ضیایی | masood ziaee
hepatitis research center, department of internal medicine, faculty of medicine, birjand university of medical sciences, birjand, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بیرجند (Birjand university of medical sciences)

فرشید عابدی | farshid abedi
department of infectious disease, mashhad university of medical sciences, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

بهروز عطایی | behrooz ataei
infectious diseases and tropical medicine research center, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مجید یاران | majid yaran
infectious diseases and tropical medicine research center, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

بابک صیاد | babak sayad
kermanshah liver diseases and hepatitis research center, kermanshah, iran.


محمدحسین صومی | mohamadhosein somi
liver and gastrointestinal disease research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

غلامرضا ساری زاده | gholamreza sarizadeh
educational region of khozestan blood transfusion organization, ahvaz, iran.

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

اسماعیل صانعی مقدم | ismail sanei moghaddam
department of gastroenterology, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

فریبرز منصور قناعی | fariborz mansour ghanaei
gastrointestinal amp;amp; liver diseases research center, guilan university of medical sciences, rasht, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

هوشنگ رفعت پناه | houshang rafatpanah
immunology research center, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حسین کیوانی | hossein keyvani
department of virology, school of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

ابراهیم کلانتری | ebrahim kalantari
gholhack medical laboratory tehran, iran.


مهدی saberfiroozi | mehdi saberfiroozi
gastroenterohepatology research center, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

رضا رضایی | reza rezaee
ministry of health and medical education, deputy of curative affairs, budget administration, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

مریم دارم | maryam daram
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


مصطفی مهابادی | mostafa mahabadi
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


زهرا گودرزی | zahra goodarzi
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.


وحدت پورطهماسبی | vahdat poortahmasebi
hepatitis b molecular laboratory-department of virology-school of public health-tehran uni- versity of medical sciences, tehran, iran.
نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/785
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