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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۵، صفحات ۳۸۹-۴۰۰
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عنوان انگلیسی Tiliacora triandra (Colebr.) Diels leaf extract enhances spatial learning and learning flexibility, and prevents dentate gyrus neuronal damage induced by cerebral ischemia/reperfusion injury in mice
چکیده انگلیسی مقاله Objective: The present study investigated the effects of a local Thai vegetable, Tiliacora triandra (Colebr.) Diels, also known as Yanang, against cerebral ischemia/reperfusion injury in mice. Materials and Methods: Thirty male ICR mice were divided into three experimental groups of BLCCAO + 10% Tween 80, BLCCAO + T. triandra 300 mg/kg, and BLCCAO + T. triandra 600 mg/kg. Cerebral ischemia/reperfusion was induced by three minutes of bilateral common carotid artery occlusion (BLCCAO) followed by 18 days of reperfusion. Leaf extract was administered orally 24 hours after arterial occlusion and continued for 18 consecutive days. Cognitive abilities were evaluated using the Morris water maze. Histological analysis was conducted in the dorsal hippocampus subregions CA1, CA3, and DG and white matter regions (the corpus callosum, internal capsule, and optic tract) using 0.1 % cresyl violet and 0.1% Luxol fast blue staining. Results: Results showed that T. triandra leaf extract at the doses of 300 and 600 mg/kg significantly enhanced spatial learning, and learning flexibility, and prevented neuronal death in the DG of mice following ischemia/reperfusion. Conclusion: T. triandra leaf extract enhanced spatial learning, and learning flexibility, and prevented DG neuronal death in a mice model of cerebral ischemia/reperfusion.
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نویسندگان مقاله wachiryah thong آسا | wachiryah thong asa
physiology division, animal toxicology and physiology specialty research unit atpru , department of zoology, faculty of science, kasetsart university, bangkok, thailand


panas tumkiratiwong | panas tumkiratiwong
physiology division, animal toxicology and physiology specialty research unit atpru , department of zoology, faculty of science, kasetsart university, bangkok, thailand


vasakorn bullangpoti | vasakorn bullangpoti
animal toxicology and physiology specialty research unit atpru , department of zoology, faculty of science, kasetsart university, bangkok, thailand


کاظم kongnirundonsuk | kasem kongnirundonsuk
faculty of science and technology, bansomdejchaopraya rajabhat university, hiranruchi, dhonburi bangkok, thailand


kanokwan tilokskulchai | kanokwan tilokskulchai
neuroscience unit, department of physiology, faculty of medicine siriraj, siriraj hospital, mahidol university, bangkok, thailand
نشانی اینترنتی http://ajp.mums.ac.ir/article_8398.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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