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Iranian Journal of Public Health، جلد ۴۶، شماره ۱۱، صفحات ۱۴۷۵-۱۴۸۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Role of Molecular Biology in Cancer Treatment: A Review Article
چکیده انگلیسی مقاله Abstract Background: Cancer is a genetic disease and mainly arises due to a number of reasons include activation of oncogenes, malfunction of tumor suppressor genes or mutagenesis due to external factors. Methods: This article was written from the data collected from PubMed, Nature, Science Direct, Springer and Elsevier groups of journals. Results: Oncogenes are deregulated form of normal proto-oncogenes required for cell division, differentiation and regulation. The conversion of proto-oncogene to oncogene is caused due to translocation, rearrangement of chromosomes or mutation in gene due to addition, deletion, duplication or viral infection. These oncogenes are targeted by drugs or RNAi system to prevent proliferation of cancerous cells. There have been developed different techniques of molecular biology used to diagnose and treat cancer, including retroviral therapy, silencing of oncogenes and mutations in tumor suppressor genes. Conclusion: Among all the techniques used, RNAi, zinc finger nucleases and CRISPR hold a brighter future towards creating a Cancer Free World.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله امان عمران | aman imran
center of excellence in molecular biology, university of the punjab, lahore, pakistan


hafiza yasara قمر | hafiza yasara qamar
center of excellence in molecular biology, university of the punjab, lahore, pakistan institute of molecular biology and biotechnology, university of lahore, lahore, pakistan


قربان علی | qurban ali
center of excellence in molecular biology, university of the punjab, lahore, pakistan


hafsa نعیم | hafsa naeem
center of excellence in molecular biology, university of the punjab, lahore, pakistan


مریم ریاض | mariam riaz
center of excellence in molecular biology, university of the punjab, lahore, pakistan


saima امین | saima amin
dept. of plant breeding and genetics, university of agriculture, faisalabad, pakistan


naila kanwal | naila kanwal
dept. of plant breeding and genetics, university of agriculture, faisalabad, pakistan southern cross plant science, southern cross university, lismore, australia


fawad علی | fawad ali
centre for applied molecular biology, university of the punjab, lahore, pakistan


محمد فاروق صابر | muhammad farooq sabar
center of excellence in molecular biology, university of the punjab, lahore, pakistan


idrees احمد نصیر | idrees ahmad nasir


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/11475
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article(s)
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