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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱۱، صفحات ۱۲۲۰-۱۲۲۶
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عنوان انگلیسی Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats
چکیده انگلیسی مقاله Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin. Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/β-catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives.
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نویسندگان مقاله qiang یانگ | qiang yang
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


wen wen ونگ | wen wen wang
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


| zhong xuan ma
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


| zhong xuan ma
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


meng hao | meng hao
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


temitope i adelusi | temitope i adelusi
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


lei du | lei du
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


محمد بن همام رییس کنفدراسیون xing yin | xiao xing yin
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china


qian lu | qian lu
jiangsu key laboratory of new drug research and clinical pharmacy, xuzhou 221002, jiangsu, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_9473.html
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نوع مقاله منتشر شده Original Article
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