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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱۱، صفحات ۱۲۴۲-۱۲۴۹
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عنوان انگلیسی The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans
چکیده انگلیسی مقاله Objective(s):We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC.   Materials and Methods: Expression of TSG-6 and uroplakin III was determined by immuno- histochemistry of bladder biopsy samples from control human subjects and patients with verified BPS/IC. Our rat model of BPS/IC was employed to measure the perfusion of bladders with hyaluronidase, and assessment of the effect of TSG-6 administration on disease progression. Treatment effects were assessed by measurement of metabolic characteristics, RT-PCR of TGR-6 and interleukin-6, bladder histomorphology, and immunohistochemistry of TGR-6 and uroplakin III. Results: The bladders of patients with BPS/IC had lower expression of uroplakin III and higher expression of TSG-6 than controls. Rats treated with hyaluronidase for 1 week developed the typical signs and symptoms of BPS/IC, and rats treated with hyaluronidase for 4 weeks had more serious disease. Administration of TSG-6 reversed the effects of hyaluronidase and protected against disease progression. Conclusion:Our results indicate that TSG-6 plays an important role in maintaining the integrity of the bladder epithelial barrier.
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نویسندگان مقاله yi song lv | yi song lv
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china


روی امتیاز | rui gao
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china


qing ming lin | qing ming lin
department of emergency medicine, fujian provincial hospital, fuzhou 350005, china


تایو jiang | tao jiang
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china


qin chen | qin chen
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china


song xi تنگ | song xi tang
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china


hou ping mao | hou ping mao
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china


هیو liang zhou | hui liang zhou
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china


lin sheng cao | lin sheng cao
department of urology, the first affiliated hospital of fujian medical university, fuzhou 350005, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_9540.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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