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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱۰، صفحات ۱۱۷۲-۱۱۷۷
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چکیده فارسی مقاله
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عنوان انگلیسی Renoprotective effect of crocin following liver ischemia/ reperfusion injury in Wistar rats
چکیده انگلیسی مقاله Objective(s): The objectives of the current study were to evaluate the effects of hepatic ‎ischemia/reperfusion (IR) injury on the activity of antioxidant enzymes, biochemical factors, and ‎histopathological changes in rat kidney, and to investigate the effect of crocin on IR-‎related changes. Materials and Methods: Thirty-two male Wistar rats were randomly allocated into four groups (n=8). They were ‎sham-operated, IR, crocin pre-treatment, and crocin pretreatment+IR groups. Sham-operated ‎and Crocin pre-treatment groups received normal saline (N/S, 2 ml/day) and crocin (200 mg/kg) ‎for seven consecutive days intraperitoneally (IP), respectively, then rats underwent laparotomy, only. ‎IR and crocin pretreatment+IR groups received N/S and crocin with the same dose, time, and route, ‎respectively, then rats underwent partial (70%) ischemia for 45 min that was followed by reperfusion ‎for 60 min. At the end of the experiment, kidney specimens were taken for histopathological and ‎antioxidant evaluations and also blood samples were obtained for biochemical analysis. Results: The results of the present study showed that crocin pre-treatment significantly increased ‎the activity of antioxidants, decreased the serum levels of liver enzymes and blood urea nitrogen ‎following IR-induced hepatic injury. Crocin also ameliorated kidney´s histopathological ‎disturbance beyond IR-induced hepatic injury. Conclusion: Crocin as an antioxidant agent protected renal insult following liver IR injury by ‎increasing the activity of antioxidant enzymes, reducing serum levels of liver enzymes, and ‎improving histopathological changes.‎
کلیدواژه‌های انگلیسی مقاله Antioxidant, Crocin, Ischemia/reperfusion Kidney, Liver, Rat
نویسندگان مقاله سید علی مرد | seyyed ali mard
research center for infectious diseases of digestive system alimentary tract research center , physiology research center prc , dept. of physiology, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

ghaidafeh اکبری | ghaidafeh akbari
research center for infectious diseases of digestive system alimentary tract research center , physiology research center prc , dept. of physiology, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

اسرافیل منصوری | esrafil mansouri
cellular and molecular research center, department of anatomic sciences, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

مهدی پارسانهاد | mahdi parsanahad
virology department, school of medicine ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_9450.html
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