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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۸، صفحات ۸۸۶-۸۹۳
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum
چکیده انگلیسی مقاله Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. Materials and Methods: Adult male C57BL/6J mice were fed a chow containing 0.2 % cuprizone for 6 weeks. After 3 weeks, mice were simultaneously treated with erythropoietin (5,000 IU/ kg body weight) by daily intraperitoneal injections. Results: Our results showed that cuprizone induced oxidative stress accompanied with down-regulation of subunits of the respiratory chain complex and demyelination of corpus callosum. Erythropoietin antagonized these effects. Biochemical analysis showed that oxidative stress induced by cuprizone was regulated by erythropoietin. Similarly, erythropoietin induced the expression of subunits of the respiratory chain complex over normal control values reflecting a mechanism to compensate cuprizone-mediated down-regulation of these genes. Conclusion: The data implicate that erythropoietin abolishes destructive cuprizone effects in the corpus callosum by decreasing oxidative stress and restoring mitochondrial respiratory enzyme activity.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله ایرج راگردی کاشانی | iraj ragerdi kashani
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین چاوشی | hossein chavoshi
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

پریچهر پاسبخش | parichehr pasbakhsh
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمود حسنی | mahmoud hassani
department of medical nanotechnologies, school of advanced technologies, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آمنه امیدی | ameneh omidi
department of anatomical sciences, medical sciences faculty, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

رضا محمودی | reza mahmoudi
cellular and molecular research center, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

cordian beyer | cordian beyer
faculty of medicine, institute of neuroanatomy, rwth aachen university, aachen, germany


ادیب زنده دل | adib zendedel
faculty of medicine, institute of neuroanatomy, rwth aachen university, aachen, germany
نشانی اینترنتی http://ijbms.mums.ac.ir/article_9110.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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