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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۵، صفحات ۵۱۱-۵۱۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
چکیده انگلیسی مقاله Objective(s): Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. Materials and Methods: A sample of 75 healthy male Wistar rats was randomly selected according to inclusion and exclusion criteria. 75 male Wistar rats were randomly divided into a control and 4 experimental groups. Streptozotocin (STZ) in citrate buffer (pH 4.5) at a dose of 45 mg/kg was injected for induction of diabetes mellitus and rats achieving fasting blood glucose >250 mg/dl were included. Blood samples were collected 18 hr after the last dose of metformin and berberine. Ethical approval was taken before the study was conducted. Staistix 10.0 (USA) software was used for data analysis. Results: Berberine decreased MALA. Metformin, metformin + BBR 50 mg/kg bwt, and metformin + BBR 100 mg/kg bwt showed serum lactate as 1.87±0.4 mmol/lL, 1.62 ± 0.44 mmol/l and 1.47± 0.45 mmol/l, respectively (P=0.0001).  Insulin resistance and liver enzymes were improved in BBR treated rats. Conclusion: The present study reports berberine protects against MALA in streptozocin-induced diabetes mellitus.
کلیدواژه‌های انگلیسی مقاله Berberine, Insulin resistance, Lactic acidosis, Metformin
نویسندگان مقاله suhail احمد آل منیع | suhail ahmed almani
department of medicine liaquat university of medical and health sciences jamshoro, sindh, pakistan


اقبال احمد memon | iqbal ahmed memon
department of medicine liaquat university of medical and health sciences jamshoro, sindh, pakistan


طارق ظفر شیخ | tariq zaffar shaikh
department of medicine liaquat university of medical and health sciences jamshoro, sindh, pakistan


حاجی خان khoharo | haji khan khoharo
faculty of medicine and allied medical sciences isra university, hyderabad, sindh, pakistan


ikramuddin ujjan | ikramuddin ujjan
department of pathology liaquat university of medical and health sciences jamshoro, sindh, pakistan
نشانی اینترنتی http://ijbms.mums.ac.ir/article_8675.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Barberry special issue
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