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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۵، صفحات ۵۵۲-۵۵۶
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عنوان انگلیسی The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats
چکیده انگلیسی مقاله Objective(s): Various studies have shown that the diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on histopathological and biochemical markers of liver in diabetic rats. Materials and Methods: In this experimental study, 60 male Wistar rats weighing 200-250 g with free access to water and ad libitum were randomly divided to five twelve-membered groups including healthy control (group 1), diabetic control (group 2, this two groups received distilled water), treated diabetic positive control (group 3) using dose 150 mg/kg/day metformin, and two groups treated with doses 200 (group 4) and 600 (group 5) mg/kg/BW of B. vulgaris extracts via gavage feeding for 8 weeks. Diabetes mellitus was experimentally induced by one dose injection of alloxan 120 mg/kg. This pre-clinical study was performed on 120 mg/kg alloxan induced diabetic rats. Results: The hepatic steatosis status, liver cholestasis and fibrosis were not changed in group 4 and 5. Glycogen deposition changed mildly and polymorphonuclear neutrophils infiltration changed moderately at group 5. Liver hepatitis changed mildly and severely at group 3 as well as group 5, respectively. Glucose, serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase were lower in high dose group compared to other groups. Conclusion: Results suggested that B. vulgaris extract can decrease liver damage by influencing hepatic histopathological and biochemical markers in diabetic rats.
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نویسندگان مقاله محمد رحیمی مدیسه | mohammad rahimi madiseh
medical plants research center, shahrekord university of medical sciences, shahrekord, iran


پریدخت کریمیان | paridokht karimian
department of pathology, shahrekord university of medical sciences, shahrekord, iran


مرضیه کافشانی | marzieh kafeshani
department of clinical nutrition community nutrition food science amp; technology, food security research center, school of nutrition amp; food science, isfahan, iran


محمود رفیعیان کوپایی | mahmoud rafieian kopaei
medical plants research center, shahrekord university of medical sciences, shahrekord, iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_8681.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Barberry special issue
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