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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۴، صفحات ۳۶۶-۳۷۵
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عنوان انگلیسی Anti-nociceptive and anti-inflammatory effects of the methanolic extract of Opuntia humifusa stem
چکیده انگلیسی مقاله Objective: Opuntia humifusa (O. humifusa) Raf. has been used for the prevention and treatment of rheumatoid arthritis, inflammation, and cancer. Our study was designed to unveil the anti-nociceptive and anti-inflammatory effects of the methanolic extract of O. humifusa Raf stem (OHS).  Material and Methods: The anti-nociceptive effect was measured by hot plate, acetic acid-induced writhing, and tail flick assays in mice and rats. Moreover, the anti-inflammatory effect was measured by vascular permeability and carrageenan and serotonin-induced paw edema tests in rats. Furthermore, anti-inflammatory effect was also measured using macrophage-like LPS-induced RAW 264.7 cells. Results: OHS extract inhibited acetic acid-induced writhing (p< 0.0001), and delayed the reaction time of mice to the hot plate-induced thermal stimulation (p< 0.0001) and tail flick tests (p< 0.05). OHS extract attenuated the carrageenan and serotonin-induced paw edema in rats (p< 0.001). Similarly, OHS extract significantly decreased Evans blue concentration in acetic acid induced vascular permeability test (p< 0.0001), revealing its strong anti-inflammatory effect. Finally, among four different fractions of OHS extract, n-butanol fraction strongly decreased NO production (p< 0.0001) and iNOS expression in LPS-induced RAW 264.7 cells. Conclusion: Our results suggest that the methanolic extract of O. humifusa stem can be used to develop a therapeutic or supportive drug and/or functional food against pain and inflammation related diseases.
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نویسندگان مقاله bhesh راژ شارما | bhesh raj sharma
department of oriental medicine resources mokpo national university, muan-gun, jeonnam 58554, republic of korea


chul امین سونگ گو | chul min park
department of oriental medicine resources mokpo national university, muan-gun, jeonnam 58554, republic of korea


جنگ چوی | jong choi
college of pharmacy, kyungsung university, busan 48434, korea


دانک یانگ rhyu | dong young rhyu
department of oriental medicine resources mokpo national university, muan-gun, jeonnam 58554, republic of korea
نشانی اینترنتی http://ajp.mums.ac.ir/article_8245.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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