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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۳، صفحات ۲۱۴-۲۲۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Potentiating effects of Perovskia abrotanoides on pentobarbital-induced sleep
چکیده انگلیسی مقاله Objective: Sleeplessness is the most common sleep disorder. In this study the hypnotic effect of the hydro-alcoholic extract (HAE) of Perovskia abrotanoides and its water fraction (WF), ethyl acetate fraction (EAF) and n-butanol fraction (NBF) were studied in mice.Materials and Methods: The test compounds were administered intraperitoneally to mice 30 min before the administration of sodium pentobarbital (30 mg/kg.). Moreover, the influence of flumazenil on the hypnotic effect of the extracts was evaluated. Besides, 30 min after administration of HAE, motor coordination (rota-rod test) was assessed. Additionally, LD50 for HAE was determined and the possible neurotoxicity of the extract was tested in neural PC12 cells.Results: The HAE and NBF decreased the latency of sleep (p< 0.05), and significantly increased the duration of sleep (p< 0.05) induced by pentobarbital. These effects of P. abrotanoides were reversed by flumazenil. HAE did not affect the animals' performance on the rota-rod test. The LD50 value for HAE was found to be 4.8 g/kg. HAE and its fractions did not show neurotoxic effects in cultured PC12 cell line.Conclusion: The results showed that P. abrotanoides significantly potentiated pentobarbital hypnosis without toxic effect. Probably, its effects are related to its non-polar constituents.
کلیدواژه‌های انگلیسی مقاله Perovskia abrotanoides, Diazepam, Sleep, PC12
نویسندگان مقاله فاطمه فروزانفر | fatemeh forouzanfar
pharmacological research center of medicinal plants, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

آذر حسینی | azar hosseini
pharmacological research center of medicinal plants, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد صادق امیری | mohammad sadegh amiri
department of biology, payame noor university, tehran, iran

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

حسن رخشنده | hasan rakhshandeh
pharmacological research center of medicinal plants, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_7793.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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