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Nanomedicine Journal، جلد ۴، شماره ۳، صفحات ۱۴۲-۱۵۱
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عنوان انگلیسی Core-shell magnetic pH-responsive vehicle for delivery of poorly water-soluble rosuvastatin
چکیده انگلیسی مقاله Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic acid (PVP-PEG-PMAA) was developed for targeted and controlled delivery of rosuvastatin. The carrier was characterized by TEM, XRD, and FT-IR techniques.Results: A typical carrier has about a 9 nm magnetite core, about 20 nm mean diameter with a narrow size distribution. The loading efficiency and pH-controlled release properties of the carrier were examined using a hydrophobic model drug rosuvastatin. Maximum loading efficiency of about 96% and a release amount of 90% of 12 hours were achieved at 37 oC in pH 1.2. While in pH 5.5 and 7.2, release amount of 25% and 37% were obtained respectively.Conclusion: The results indicate that the prepared pH-responsive polymer which covalently coated around magnetic nanoparticles is an efficient carrier with good loading capacity and controlled-release property.
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نویسندگان مقاله میترا آملی دیوا | mitra amoli diva
department of chemistry, payam noor university pnu , tehran, iran


کامیار پورقاضی | kamyar pourghazi
department of chemistry, karazmi tarbiat moalem university, tehran, iran|department of research and development, darupakhsh pharmaceutical co., tehran, iran
نشانی اینترنتی http://nmj.mums.ac.ir/article_8955.html
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