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Asia Pacific Journal of Medical Toxicology، جلد ۶، شماره ۲، صفحات ۴۷-۴۹
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عنوان انگلیسی Toxicological Screening of Drug Facilitated Crime among Travelers in Dhaka, Bangladesh
چکیده انگلیسی مقاله Introduction: Drug-facilitated robberies, primarily of public transport passengers, are a massively increasing public health emergency and law enforcement challenge in Dhaka, the capital city of Bangladesh. Methods:We conducted a prospective clinical and toxicological study of 38 patients with acute poisoning who had been admitted to Dhaka Medical College Hospital between October 2008 and December 2008 and suspected to be victims of drug-facilitated crimes. Blood samples were obtained on admission and one hour later to identify changing concentrations of the drugs used by the perpetrators. Toxicological screening was performed by LC-TOF/MS and LC-MS/MS analysis of the blood samples of 22 of these patients. Results:All of the patients in our series were male, 17-60 years of age, and none had any memory of the time between the ingestion of the drug and the onset of unconsciousness. All had lost the valuables they had been carrying at the time of the incident. On admission, 50% of the patients had a Glasgow Coma Score (GCS) of 5-10. Most of them were poisoned while travelling (79%), most frequently by bus (70%). They had been offered tea (21%), other drinks (26%), prickles (18%), herbal medicines (10%) or cigarettes (5%) by the suspected perpetrators. Screening by LC-TOF/MS and LC-MS/MS revealed pharmacologically active concentrations of lorazepam in the blood samples of all 22 cases (191±138 µg/l, mean±SD); midazolam in 12 (149±99 µg/l); diazepam in 3 (217±144 µg/l) and nordiazepam in 6 cases (364±186 µg/l). In five cases the lorazepam concentration of the second blood sample was at least 15% higher than in the sample drawn on admission one hour earlier, indicating continuing absorption. This suggests that only these five patients had been admitted within the 1-2 hour long absorption phase. Almost all of the patients left the hospital unnoticed after clearing up, two likely prematurely within 12 hours of admission, and no mortality was observed. Conclusions:This study reveals flexibility of the criminals in Dhaka in using different mixtures of benzodiazepines to incapacitate and then rob their victims.The findings of our study have important implications for the clinical management of drug-facilitated crime victims. In particular, they highlight an urgent need to widely deploy rapid diagnostic and analytical forensic and clinical toxicology facilities in Bangladesh, introduce and implement modifications to emergency department protocols, and provide post-recovery psychological support for victims who often suffer existentially threatening economic losses in addition to the poisoning.
کلیدواژه‌های انگلیسی مقاله Benzodiazepine, Commuters, Poisonings
نویسندگان مقاله ariful basher | ariful basher
resident,critical care medicine , bangabandhu sheikh mujib medical university, dhaka, bangladesh


m فیض | m faiz
professor of medicine retired , dev care foundation, dhaka, bangladesh


سید عارف | syed arif
associate professor of medicine, dhaka medical college, dhaka, bangladesh


mak khandaker | mak khandaker
professor of medicine, popular medical college, dhaka, bangladesh


ulrich kuch | ulrich kuch
institute of occupational medicine, social medicine and environmental medicine, centre of health sciences, goethe university, frankfurt am main, germany


sw toennes | sw toennes
institute of forensic toxicology, centre for legal medicine, goethe university, frankfurt am main, germany
نشانی اینترنتی http://apjmt.mums.ac.ir/article_8949.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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