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Asia Pacific Journal of Medical Toxicology، جلد ۶، شماره ۲، صفحات ۶۲-۶۶
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عنوان انگلیسی Acute Kidney Injury, Myocardial Infarction and Death Following Brake Fluid Poisoning; A Case Report
چکیده انگلیسی مقاله Background: Ethylene glycol is a toxic alcohol which is used in brake fluid, antifreeze, coolants, preservatives and chemical solvents. Ethylene glycol poisoning usually results in depression of the central nervous system, renal insufficiency and cardiopulmonary compromise, while laboratory findings include metabolic acidosis, increased anion gap, increased osmolar gap and calcium oxalate crystalluria. Case presentation: A 24-year-old previously healthy person died 13 days after self-ingestion of brake fluid (ethylene glycol). He developed multi-organ failure including acute kidney injury, metabolic acidosis, respiratory failure, myocardial infarction, low Glasgow coma scale, and elevation of liver enzymes. He also developed hypotension for which 3 inotropes were started. He had ST elevation myocardial infarction (STEMI) on day 4 of the poisoning associated with a reduction of ejection fraction of up to 25% with septal anterior wall hypokinesia. He needed intensive care treatment via ventilator and inotropic support. Five cycles of hemodialysis were carried out for acute kidney injury. His autopsy examination revealed sub-endocardial hemorrhages. Discussion: Acute kidney injury and metabolic acidosis are frequently seen following ethylene glycol poisoning from brake fluid ingestion. The cardiotoxic effect of its poisoning could be due to multiple microcalcifications of the myocardium. This clinical report highlights the severity and the sequence of events following ethylene glycol poisoning. Conclusion: STEMI may result following ethylene glycol poisoning in addition to other cardiac effects such as hypotension, tachycardia, myocarditis and ischemic changes in ECG.
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نویسندگان مقاله rathnayaka mudiyanselage mithun kaushika namal rathnayaka | rathnayaka mudiyanselage mithun kaushika namal rathnayaka
department of veterinary pathobiology, faculty of veterinary medicine and animal science, university of peradeniya, sri lanka. medical officer-intensive care unit anaesthesia provincial general hospital, ratnapura


panwilahene ellawatte anusha nishanthi ranathunga | panwilahene ellawatte anusha nishanthi ranathunga
medical unit, provincial general hospital, ratnapura, sri lanka
نشانی اینترنتی http://apjmt.mums.ac.ir/article_8953.html
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نوع مقاله منتشر شده Case Report
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