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Iranian Journal of Toxicology، جلد ۱۱، شماره ۶، صفحات ۷-۱۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats
چکیده انگلیسی مقاله Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human.  Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via intratracheal tube (n=6) in 2015. Sham group received normal saline. Saffron aqueous extract (50 mg/kg and 100 mg/kg) were given orally in two different treated groups with bleomycin for 28 days. Lung Indices was calculated at the end of this experiment. Lung segments fixed in 10% formaldehyde were used for pathological preparation with Hematoxylin & Eosin and trichrome staining. Results: The body weight was decreased and lung Indices increased in bleomycin group (P< 0.5). Bleomycin administration increased myeloperoxidase, malondialdehyde and finally TNF-α in lung tissue homogenates (P< 0.05) compared with sham group. The fibrotic process and thickening of alveolar septa in treated rats with bleomycin were increased by H&E and Masson Trichrome staining. Saffron treatment (50 and 100 mg/kg) attenuated the increase in MDA (264.43±10.4 nmol/g by the higher dose versus 378.4±18.1nmol/g), MPO (0.19±0.03 and 0.13± 0.04 IU/ml versus 0.39.2±0.05 IU/ml) and TNF-α level (18.42±3.7 ng/ml and14.31±3.6 ng /ml versus 35.32±4.2) in lung homogenates compared to bleomycin group (P< 0.05). It decreased collagen accumulation and alveolar destructive patterns in pulmonary fibrosis. Conclusion: This study introduces saffron as novel anti-fibrotic agent against bleomycin-induced fibrosis due to histological examinations and preventive effects on destructive enzyme release in rats.
کلیدواژه‌های انگلیسی مقاله Bleomycin, Fibrosis, Rat, Saffron
نویسندگان مقاله مهرزاد بحتویی | mehrzad bahtouee
department of internal medicine, bushehr university of medical sciences, bushehr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

حسین فاطمی کیا | hossein fatemikia
departments of physiology, faculty of medicine, bushehr university of medical sciences, bushehr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

خلیل پورخلیلی | khalil pourkhalili
departments of physiology, faculty of medicine, bushehr university of medical sciences, bushehr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

euikyung کیم | euikyung kim
department of toxicology, college of veterinary medicine, gyeongsang national university, jinju, south korea.


حمیدرضا رحیمی | hamid reza rahimi
departments of physiology, faculty of medicine, bushehr university of medical sciences, bushehr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

زهرا طاوسی | zahra tavosi
departments of physiology, faculty of medicine, bushehr university of medical sciences, bushehr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

عبدالحمید اسماعیلی | abdol hamid esmaili
departments of physiology, faculty of medicine, bushehr university of medical sciences, bushehr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

عبدالله حاجی وندی | abdollah hajivandi
department of biostatistics, faculty of hygiene, bushehr university of medical sciences, bushehr,iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

یعقوب حسن | yaghoob hassan
msc of nutrition, research committee, faculty, bushehr university of medical science, bushehr, iran.


رامین سیدیان | ramin seyedian
department of pharmacology and toxicology, bushehr university of medical sciences, bushehr,iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-76-2&slc_lang=en&sid=en
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