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The Archives of Bone and Joint Surgery، جلد ۵، شماره ۶، صفحات ۳۵۱-۳۶۲
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عنوان انگلیسی Association between ESRα Gene Pvu II T>C, XbaI A>G and BtgI G>A Polymorphisms and Knee Osteoarthritis Susceptibility: a Systematic Review and Meta-Analysis based 22 on case-control studies
چکیده انگلیسی مقاله Background: Many studies have reported the association of estrogen receptor α gene (ESRα) ESRα PvuII T>C, XbaI A>G and BtgI G>A polymorphisms with Knee osteoarthritis (KOA) risk, but the results remained controversial. In order to drive a more precise estimation, the present systematic review and meta-analysis was performed to investigate the association between ESRα polymorphisms and KOA susceptibility. Methods: Eligible articles were identified by search of databases including PubMed, ISI Web of Knowledge and Google scholar up to March 2017. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results: A total of 22 case-control studies in eleven publications with 6,575 KOA cases and 7,459 controls were included in the meta-analysis. By pooling all the studies, either ESRα PvuII T>C and XbaI A>G polymorphisms was not associated with KOA risk in the overall population. However, ESRα BtgI G>A was significantly associated with KOA risk under all five genetic models. In the subgroup analysis by ethnicity, a significant association was observed between ESRα PvuII T>C polymorphism and KOA risk in Asians under heterozygote model. In addition, significant association was found between ESRα XbaI A>G polymorphism and KOA in Caucasians under allelic, homozygote, dominant and recessive models. Conclusion: The present meta-analysis suggests that ESRα BtgI G>A rather than ESRα PvuII T>C and XbaI A>G polymorphisms is associated with an increased KOA risk in overall population. Moreover, we have found that ESRα PvuII T>C and XbaI A>G polymorphisms associated with KOA susceptibility by ethnicity backgrounds.
کلیدواژه‌های انگلیسی مقاله Osteoarthritis, Knee, estrogen receptor gene, polymorphism
نویسندگان مقاله مسعود مهدی نژاد یزدی | masoud mehdinejad yazdi
department of orthopedics, afshar hospital, shahid sadoughi university of medical sciences, yazd, iran


محمد حسین جمال الدینی | mohamad h jamalaldini
department of orthopedics, shahid sadoughi hospital, shahid sadoughi university of medical sciences, yazd, iran


محمدرضا سبحان | mohammad r sobhan
department of orthopedics, shahid sadoughi hospital, shahid sadoughi university of medical sciences, yazd, iran


محمدعلی جعفری | mohammadali jafari
department of emergency medicine, shahid sadoughi hospital, shahid sadoughi university of medical sciences, yazd, iran


مهتا مظاهری | mahta mazaheri
department of medical genetics, shahid sadoughi university of medical sciences, yazd, iran mother and newborn health research center, shahid sadoughi university of medical sciences, yazd, iran


مسعود عاطفی | masoud zare shehneh
department of medical genetics, shahid sadoughi university of medical sciences, yazd, iran


حسین نعمت زاده | hossein neamatzadeh
department of medical genetics, shahid sadoughi university of medical sciences, yazd, iran mother and newborn health research center, shahid sadoughi university of medical sciences, yazd, iran
نشانی اینترنتی http://abjs.mums.ac.ir/article_9534.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده SYSTEMATIC REVIEW
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