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The Archives of Bone and Joint Surgery، جلد ۵، شماره ۶، صفحات ۴۰۴-۴۱۶
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عنوان انگلیسی Effects of Human Adipose-derived Stem Cells and Platelet-rich Plasma on Healing Response of Canine Alveolar Surgical Bone Defects
چکیده انگلیسی مقاله Background: Due to the known disadvantages of autologous bone grafting, tissue engineering approaches havebecome an attractive method for ridge augmentation in dentistry. To the best of our knowledge, this is the first studyconducted to evaluate the potential therapeutic capacity of PRP-assisted hADSCs seeded on HA/TCP granules onregenerative healing response of canine alveolar surgical bone defects. This could offer a great advantage to alternativeapproaches of bone tissue healing-induced therapies at clinically chair-side procedures.Methods: Cylindrical through-and-through defects were drilled in the mandibular plate of 5 mongrel dogs and filledrandomly as following: I- autologous crushed mandibular bone, II- no filling material, III- HA/TCP granules in combinationwith PRP, and IV- PRP-enriched hADSCs seeded on HA/TCP granules. After the completion of an 8-week period ofhealing, radiographic, histological and histomorphometrical analysis of osteocyte number, newly-formed vessels andmarrow spaces were used for evaluation and comparison of the mentioned groups. Furthermore, the buccal side ofmandibular alveolar bone of every individual animal was drilled as normal control samples (n=5).Results: Our results revealed that hADSCs subcultured on HA/TCP granules in combination with PRP significantlypromoted bone tissue regeneration as compared with those defects treated only with PRP and HA/TCP granules (P< 0.05).Conclusion: In conclusion, our results indicated that application of PRP-assisted hADSCs could induce bone tissueregeneration in canine alveolar bone defects and thus, present a helpful alternative in bone tissue regeneration.
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نویسندگان مقاله ریحانه شفیعیان | reyhaneh shafieian
department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مریم مقدم متین | maryam moghadam matin
stem cell and regenerative medicine research group, academic center for education, culture and research acecr , khorasan razavi branch, mashhad, iran


امین راه پیما | amin rahpeyma
oral and maxillofacial diseases research center, school of dentistry, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا فاضل | alireza fazel
microanatomy research center, school of medicine, mashhad university of medical sciences, mashhad, iran department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حمیده سالاری صدیق | hamideh salari sedigh
department of clinical sciences, faculty of veterinary medicine, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

آریانه صدر نبوی | ariane sadr nabavi
department of genetics, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حلیمه حسن زاده | halimeh hassanzadeh
stem cell and regenerative medicine research group, academic center for education, culture and research acecr , khorasan razavi branch, mashhad, iran


علیرضا ابراهیم زاده بیدسکان | alireza ebrahimzadeh bideskan
microanatomy research center, school of medicine, mashhad university of medical sciences, mashhad, iran department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://abjs.mums.ac.ir/article_9123.html
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