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Iranian Journal of Blood and Cancer، جلد ۷، شماره ۳، صفحات ۱۳۵-۱۴۱
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عنوان انگلیسی Detection Of 11q23 Gene Rearrangement In Children With Acute Lymphoblastic Leukemia And Its Association With Demographic Data and Response To Initial Chemotherapy On The Seventh Day Of Induction
چکیده انگلیسی مقاله Background: Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer leading to cancer-related death in children. Most infants with ALL harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. Mixed-lineage leukemia-rearrangement (MLL-rearrangement) at 11q23 occurs in at least two-thirds of infants with ALL. The most common MLL rearrangements are t(411)(q21q23)/MLL-AFF1 (AF4) found in approximately 50% of patients. Methods: Forty children with ALL were enrolled in our study. 11q23 rearrangement and its association with other prognostic factors such as age, sex, initial WBC, organomegaly, immunophenotype, and therapeutic response on the seventh day of induction were studied. Results: Four patients including three (11.5%) boys and one (7.1%) girl were positive for 11q23 translocation. There was no association between 11q23 rearrangement and sex, age, and initial WBC counts. None of the patients with 11q23 translocation showed blast count less than 5% in the bone marrow on the seventh day of induction (P=0.002). Conclusion: There was a significant correlation between 11q23 translocation with lack of initial response to chemotherapy. Keywords: Acute lymphoblastic leukemia, 11q23 translocation, Cytogenetic, Infant acute lymphoblastic leukemia, prognosis, Induction failure
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نویسندگان مقاله القاصی a | alghasi a
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


پدرام m | pedram m
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


ساکی n | saki n
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


سالاری f | salari f
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


جاسب k | jaseb k
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


امین اصنافی a | aminasnafi a
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


یوسفی h | yousefi h
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


ساکی مالحی a | saki malehi a
department of biostatistics and epidemiology, school of public health, ahvaz jundishapur university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

نوروزی f | noroozi f
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


معین زاده l | moeinzadeh l
health research institute, research center of thalassemia hemoglobinopathy, ahvaz jundishapur university of medical s


گله داری h | galehdari h
department of genetics, shahid chamran university, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

malekaskar am | malekaskar am
department of genetics, qom university of medical sciences, qom, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قم (Qom university of medical sciences)

نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-9-50&slc_lang=en&sid=en
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