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Iranian Journal of Blood and Cancer، جلد ۶، شماره ۲، صفحات ۶۹-۷۴
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عنوان انگلیسی Alternation in Erythrocyte Enzyme Antioxidant Activity during Blood Storage
چکیده انگلیسی مقاله Background: Blood is permanently exposed to oxidation stress and therefore has a high antioxidants capacity. Many different factors increasing the demand for the antioxidant capacity can be observed in the stored blood of donors. Consequently, damage to erythrocytes by free radicals may occur. So it is useful to control the alternation of anti-oxidant enzymes in stored blood at different days of storage. The aim of the present study was to determine the alternation of erythrocyte superoxide dismutase and glutathione peroxidase enzyme activities in stored blood. Material and Methods: Blood samples were obtained from 67 donors with average age of 26 years. Samples were collected in CPDA-1 anticoagulation solution. Erythrocyte superoxide dismutase and glutathione peroxidase enzyme activities were determined using Kei Satoh method and kits from Randox. The measurements were performed at the days 1, 7, 14, 21, 28 and 35 of storage. The blood bags were stored after each sampling at 4◦C. Data were analyzed using analytical variance statistical test and SPSS version16 software. Results: The erythrocyte levels of erythrocyte superoxide dismutase and glutathione peroxidase enzyme activities decreased significantly at the day 14th (P< 0.001) of storage compared to day 1. Conclusion: Our results suggest that during blood storage, antioxidant defense in erythrocytes were depleting gradually depending on the day of storage. Based on our finding a 14 days period can be considered a safe storage limit for transfusion in relation to oxidative stress on the RBCs in storage medium. Key words: Red blood cell, oxidative damage, antioxidant enzymes, blood storage.
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نویسندگان مقاله محمدرضا دیهیم | mohammad reza deyhim
clinical chemistry laboratory, iranian blood transfusion research center, high institute for research and education in

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

زهرا نبوی | zahra nabavi
biochemistry department, islamic azad university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محمد علی جلیلی | mohammad ali jalili
clinical chemistry laboratory, iranian blood transfusion research center, high institute for research and education in

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

مهتاب مقصودلو | mahtab maghsoudloo
clinical chemistry laboratory, iranian blood transfusion research center, high institute for research and education in

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

فهیمه خوش نقش | fahimeh khoshnaghsh
clinical chemistry laboratory, iranian blood transfusion research center, high institute for research and education in

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-1-64&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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