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Iranian Journal of Blood and Cancer، جلد ۵، شماره ۴، صفحات ۱۳۷-۱۴۳
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عنوان انگلیسی Evaluation of bone mineral density in long-term survivors of childhood acute lymphoblastic leukemia
چکیده انگلیسی مقاله Background: The purpose of this study was to evaluate long-term changes in bone density profile among survivors of childhood acute lymphoblastic leukemia. Patients and Methods: This was a 5 year prospective study comprised of thirty-one survivors of childhood acute lymphoblastic leukemia with a mean age of 11.8 (4.6) years, who completed therapy at least 1 year previously (according to the ALL-6 therapeutic protocol), and remained in complete continuous remission. BMD was measured from the lumbar spines (L2 to L4) and femoral neck, at baseline (2006) and after 5 years (2011), using dual energy x-ray absorbtiometry. Bone mineral density Z score and bone mineral content were calculated for both lumbar spine and femoral neck. Results: The mean femoral bone mineral density was 0.69 in 2006 and 0.82 in 2011 (p=0.005). The mean femoral Z score was -1.38 in 2006 and -0.55 in 2011 (p=0.006). For the lumbar spine, the mean bone mineral density was 0.71 in 2006 and 0.88 in 2011 (p=0.000) and the mean Z score was -2.08 in 2006 and -0.93 in 2011 (p=0.000) respectively. All three indices significantly changed through-out the study period. The general linear regression analysis revealed that daily calcium intake was an important predictor of lumbar spine BMD Z score. Femoral neck BMD Z score was correlated with the serum vitamin D level. Conclusion: Osteopenia in survivors of childhood acute lymphoblastic leukemia constitutes an important health risk. Patients and their families should be encouraged to take sufficient amount of calcium and vitamin D during chemotherapy and afterward. Keywords: Acute lymphoblastic leukemia, bone mineral density, bone mineral content, dual energy x-ray absorbtiometry (DXA), Iran.
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نویسندگان مقاله روحانی f | rohani f
pediatric endocrinologist, department of pediatrics endocrinology and metabolism, ali asghar children’s hos


ارجمندی kh | arjmandi kh
pediatric hematologist and oncologist, ali asghar hospital; tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زارع f | zareh f
pediatrist, department of pediatric endocrinology and oncology , ali-asghar pediatric hospital, tehran university of med

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

صنیعی s | sanii s
pediatrist, department of pediatric endocrinology and oncology , ali-asghar pediatric hospital, tehran university of med

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-1-42&slc_lang=en&sid=en
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