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Iranian Journal of Blood and Cancer، جلد ۵، شماره ۳، صفحات ۹۹-۱۰۵
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Short-term Chelating Efficacy of Deferoxamine in Iron Overloaded Rat Hepatocytes
چکیده انگلیسی مقاله Abstract Background: Iron overload is a clinical consequence of repeated blood transfusions and causes significant organ damage, morbidity, and mortality in the absence of proper treatment. The primary targets of Iron chelators used for treating transfusional Iron overload are the prevention of Iron ingress into tissues and its intracellular scavenging. The present study was aimed at elucidating the capacity of clinically important Iron chelator, deferoxamine to gain access to intracellular Iron pools of key Iron accumulating cells (hepatocytes). Material and methods: The study was conducted as an in vivo investigation. Iron-rich chow fed rats and regular chow fed rats were given deferoxamine and hepatic Iron concentration was measured using atomic absorption spectroscopy. Results: In Iron-loaded rats, the results showed that deferoxamine did not alter hepatocyte Iron levels compared with the control group but increased urinary excretion. Conclusion: We conclude that short term deferoxamine treatment is ineffective in Iron removal from rat hepatocytes. Key words: Deferoxamine, Iron overload, hepatocytes.
کلیدواژه‌های انگلیسی مقاله Deferoxamine, Iron overload, hepatocytes
نویسندگان مقاله | s kalanaky
. iranian blood transfer organization, tehran, iran.


علیرضا فارسی نژاد | alireza farsinejad
department of physiology and cardiovascular research center, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

سعیده فخارزاده | saeede fakharzade
iranian blood transfer organization, tehran, iran


محمد علی کرباسیان | mohammad ali karbasian
iranian blood transfer organization, tehran, iran


مرتضی کشاورز | morteza keshavarz
iranian blood transfer organization, tehran, iran


عظیم مهرور | azim mehrvar
pediatric hematologist oncologist, mahak children hospital, tehran-iran.


نرجس مهرور | narjes mehrvar
research department, mahak children hospital


مریم رهبر | maryam rahbar
semnan university of medical sciences , semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

محمد فرانوش | mohammad faranoush
pediatric hematologist oncologist, iranian blood transfer organization, tehran, iran.
نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-1-36&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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