این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Blood and Cancer، جلد ۵، شماره ۳، صفحات ۱۱۵-۱۲۰
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عنوان انگلیسی Treatment of a Child with Refractory Acute Myeloid Leukemia with Humanized Anti-CD33 Monoclonal Antibody: A Case Report and Review of Drug Development
چکیده انگلیسی مقاله Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozogamicin has been used to induce remission in relapsed patients. Report of the case: Here, we report the first Iranian child, an 8-year-old boy, with refractory acute myeloid who was treated with gemtuzumab ozogamicin. Unfortunately, remission was not achieved and the patient died of neutropenia and septic shock. Conclusion: Gemtuzumab ozogamicin therapy in our case was not successful in achieving remission. It could be due to longstanding chemotherapy and its detrimental effects on bone marrow of the patient. Further controlled studies are necessary to learn more about efficacy and safety of this new treatment. Keywords: Childhood acute myeloid leukemia, refractory, treatment, gemtuzumab ozogamicin
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نویسندگان مقاله ثمین علوی | samin alavi
pediatric congenital hematologic disorders research center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمد تقی ارزانیان | mohammad taghi arzanian
pediatric congenital hematologic disorders research center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-1-39&slc_lang=en&sid=en
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