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Iranian Journal of Blood and Cancer، جلد ۴، شماره ۱، صفحات ۱۹-۲۳
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عنوان انگلیسی Epidemiological features of Central Nervous System tumors at MAHAK Pediatric Cancer Treatment and Research Center
چکیده انگلیسی مقاله Background: In this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to MAHAK Pediatric Cancer Treatment and Research Center (one of the main national referral centers for childhood malignancies in Iran) for treatment. Materials and Methods: This cohort (simple sampling) study consisted of 198 children less than 15 year old with CNS tumor referred to MAHAK Pediatric Cancer Treatment and Research Center from 2007 to 2010. The unique checklist contained epidemiological features filled for each individual. Results: Out of studied patients 125(63.1%) were male and 73(36.9%) were female. The mean age of patients was 6.11±3.65 years. Tumors were located in supratentorial (N=60, 30.3%), infratentorial (N=134, 67.7%) and spinal (N=4, 2%) regions. High-grade glioma and medulloblastoma were the most common tumors in supratentorial and infratentorial locations respectively. The majority of patientin medulloblastoma group had T2M0 (N=44, 22.2%) stage. Thirty-one (15.7%) patients had arelapse. There were 38.4% treatment and 41.4% death. The five years survival rate among patients was 28%. Conclusion: The same frequency of CNS tumors in children less than 15 years old referred to MPCTRC was observed compared to other studies. The sex incidence, the mean age at presentation, tumor sites, brain tumor’s pathologies, signs and symptoms, metastases and relapses were also in line with other studies. There were significant differences in terms of high consanguinity rate and high incidence of familial cancer history as compared to reports from others. Keywords: Brain, tumor, infratentorial, supratentorial, spinal, treatment, childhood.
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نویسندگان مقاله a مهرور | a mehrvar
paediatric haematologist-oncologist, mahak paediatric cancer treatment and research center, army medical university, teh


m فرانوش | m faranoush
paediatric haematologist-oncologist, mahak paediatric cancer treatment and research center, iranian blood tr


aa هدایتی اصل | aa hedayati asl
paediatric haematologist-oncologist, mahak paediatric cancer treatment and research center, tehran, iran.


m تشویقی | m tashvighi
paediatric haematologist-oncologist, mahak paediatric cancer treatment and research center, islamic azad university gho

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

ma فاضلی | ma fazeli
pediatrician, mahak paediatric cancer treatment and research center, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی قم (Islamic azad university of ghom)

n مهرور | n mehrvar
mahak paediatric cancer treatment and research center, tehran, iran.


r روان پارسا | r ravan parsa
md, islamic azad university

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

b ثبوتی | b sobuti
md, mahak paediatric cancer treatment and research center, tehran, iran


a جعفرپور | a jafarpour
md, mahak paediatric cancer treatment and research center, tehran, iran


r زنگویی | r zangooei
md, mahak paediatric cancer treatment and research center, tehran, iran


m آل بویه | m alebouyeh
professor of paediatric haematology-oncology, mahak paediatric cancer treatment and research center, tehran, iran


p وثوق | p vossough
professor of paediatric haematology-oncology, mahak paediatric cancer treatment and research center, tehran, iran.
نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-9-13&slc_lang=en&sid=en
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