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Iranian Journal of Blood and Cancer، جلد ۲، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی Frequency of Human Platelet Antigens (HPA-2/3/5) Polymorphism in Iranians Evaluated by RFLP-PCR
چکیده انگلیسی مقاله ackground: Knowing the human platelet antigens (HPA) and genes frequency in different populations is important not only for population studies but also for clinical transfusion practice. HPA genes frequency in Iran is not evaluated, so we investigated the HPA-2, HPA-3, and HPA-5 frequency and their polymorphism. Materials and Methods: DNA from 120 Iranians (99 Iranian blood donors and 21 patients with platelet refractoriness) was isolated from peripheral blood mononuclear leucocytes and tested by restricted fragment length polymorphism analysis (RFLP). Results: The frequency of HPA phenotypes was determined as follows: (in donors) HPA-2a/2a:75.4%, HPA-2a/2b:24.8%, HPA-3a/3a:8.1%, HPA-3a/3b:70.7%, HPA-3b/3b:21.2%, HPA-5a/5a:99 % and HPA-5a/5b:1% (in patients) HPA-2a/2a:66.7%, HPA-2a/2b:33.3%, HPA-3a/3a:23.8%, HPA-3a/3b: 47.6%, HPA-3b/3b:28.6%, HPA-5a/5a:90.5%, and HPA-5a/5b: 9.5%. Frequency of genotypes evaluated by RFLP were as below: HPA-2a=0.87, HPA-2b=0.13, HPA-3a =0.28, HPA-3b=0.72, HPA-5a=0.99, and HPA-5b=0.01 in both donors and patients. Conclusion: HPA gene frequencies observed in Iranians were in the range obtained in previous studies but not exactly equal to other populations. It might be due to their relations with other populations. There was not any significant difference between two groups in this study.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مژگان شایگان | mojgan shaiegan
research center of iranian blood transfusion organization, tehran, iran.

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

شهرام سمیعی | shahram samiei
research center of iranian blood transfusion organizaon, tehran, iran.


زهرا عطایی | zahra ataee
research center of iranian blood transfusion organizaon, tehran, iran


طاهره مدنی | tahereh madani
research center of iranian blood transfusion organizaon, tehran, iran.

سازمان های دیگر: Kashan University of Medical Science, Kashan, Iran

جهانگیر احمدی | jahangir ahmadi
research center of iranian blood transfusion organizaon, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)
سازمان های دیگر: Arad Hospital, Tehran, Iran.

آزیتا آذرکیوان | azita azarkeivan
research center of iranian blood transfusion organizaon, tehran, iran

سازمان های دیگر: Adult Thalassemic Paent Clinic, Tehran, Iran.

لیلا کسراییان | leila kasraian
research center of iranian blood transfusion organizaon, tehran, iran

سازمان های دیگر: Shiraz Blood Center, Shiraz,

نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-2-238&slc_lang=en&sid=en
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