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Iranian Journal of Blood and Cancer، جلد ۲، شماره ۲، صفحات ۴۹-۶۰
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عنوان انگلیسی Molecular Markers in Neuroblastoma
چکیده انگلیسی مقاله Neuroblastoma, one of the common malignant childhood tumors, arises from neuroblast cells derived from theneural crest and destined for the adrenal medulla and the sympathetic nervous system and shows remarkable biologicalheterogeneity, resulting in favorable or unfavorable outcomes. Some tumors make rapid progress with a fataloutcome. In other instances, the tumors regress spontaneously in infants or to differentiate into a benign ganglioneuromain older patients. This heterogeneity within neuroblastoma depends on the molecular characteristics of tumorcells. Several distinct genomic alterations have been found in neuroblastoma, including MYCN amplification, DNAploidy, deletion of the short arm of chromosome 1, gain of chromosome 17q, and deletion of 11q. The difference ofexpression was also found in genes related to cellular growth, differentiation, and apoptosis of neural network includingsignaling by NTRK1 or ALK receptor tyrosine kinases, and telomerase activity. And this presentation discussesdiagnostic and prognostic molecular makers for extensive heterogeneity of neuroblastoma. This should lead to morerisk-adapted therapies according to the genetic markers by which individual neuroblastomas are biologically characterized.
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نویسندگان مقاله eiso hiyama | eiso hiyama
natural science center for basic research and development


نیومی کمایی | naomi kamei
department of pediatric surgery, hiroshima univer sity hospital, hiroshima university


arata kamimatsuse | arata kamimatsuse
department of pediatric surgery, hiroshima univer sity hospital, hiroshima university
نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-2-170&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 5
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