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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۱، صفحات ۵۹-۶۹
عنوان فارسی
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عنوان انگلیسی Metabolomics diagnostic approach to mustard airway diseases: a preliminary study
چکیده انگلیسی مقاله Objective(s): This study aims to evaluate combined proton nuclear magnetic resonance (1H NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS) metabolic profiling approaches, for discriminating between mustard airway diseases (MADs) and healthy controls and for providing biochemical information on this disease. Materials and Methods: In the present study, analysis of serum samples collected from 17 MAD subjects and 12 healthy controls was performed using NMR. Of these subjects, 14 (8 patients and 6 controls) were analyzed by GC-MS. Then, their spectral profiles were subjected to principal component analysis (PCA) and orthogonal partial least squares regression discriminant analysis (OPLS-DA). Results: A panel of twenty eight metabolite biomarkers was generated for MADs, sixteen  NMR-derived metabolites (3-methyl-2-oxovaleric acid, 3-hydroxyisobutyrate, lactic acid, lysine, glutamic acid, proline, hydroxyproline, dimethylamine, creatine, citrulline, choline, acetic acid, acetoacetate, cholesterol, alanine, and lipid (mainly VLDL)) and twelve GC-MS-derived metabolites (threonine, phenylalanine, citric acid, myristic acid, pentadecanoic acid, tyrosine, arachidonic acid, lactic acid, propionic acid, 3-hydroxybutyric acid, linoleic acid, and oleic acid). This composite biomarker panel could effectively discriminate MAD subjects from healthy controls, achieving an area under receiver operating characteristic curve (AUC) values of 1 and 0.79 for NMR and GC-MS, respectively. Conclusion: In the present study, a robust panel of twenty-eight biomarkers for detecting MADs was established. This panel is involved in three metabolic pathways including aminoacyl-tRNA biosynthesis, arginine, and proline metabolism, and synthesis and degradation of ketone bodies, and could differentiate MAD subjects from healthy controls with a higher accuracy.
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نویسندگان مقاله بی بی فاطمه نوبخت mothlagh قوچانی | bibi fatemeh nobakht mothlagh ghoochani
department of basic medical sciences, neyshabur university of medical sciences, neyshabur, iran


رسول علیان نژاد | rasoul aliannejad
pulmonary department, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

افسانه عارفی اسکویی | afsaneh arefi oskuei
department of basic sciences, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مصطفی رضایی طاویرانی | mostafa rezaei tavirani
proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

شیوا کلانتری | shiva kalantari
chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمد تقی ناصری | mohammad taghi naseri
department of chemistry, faculty of sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

علیرضا باغبان | alireza bagheban
physiotherapy research center, school of rehabilitation, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

هادی پرستار | hadi parastar
department of chemistry, sharif university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی شریف (Sharif university of technology)

غزاله علی اکبرزاده | ghazale aliakbarzadeh
department of chemistry, faculty of science, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_9924.html
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