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Avicenna Journal of Phytomedicine، جلد ۸، شماره ۱، صفحات ۸۵-۹۵
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عنوان انگلیسی Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice
چکیده انگلیسی مقاله Objectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determined by nine complementary test methods namely, open field, locomotor activity, hole cross, hole board test, elevated plus maze, staircase, forced swimming test, and rotarod test. Male mice (Swiss-Webster strain, 20-40 g body weight) bred in the Animal House of the Department of Pharmacy, Jahangirnagar University, were used for the pharmacological experiments. Results: The drug decreased total ambulation and movement in the central region and standing up behavior and lowered emotional defecation. The drug also made the mice to take a shorter time to come out of the cage. Also, animals spent less time in open arm and the movement in the closed arm and locomotors reduced (p=0.003), where a number of rearing (p=0.04) behaviour indicating possible anxiolytic activity.  Also, no signs of anti-depressant activity were observed among SKC-treated group. Conclusion: We concluded that our drug showed no neurotoxic effect and it also showed some beneficial neuropharmacological properties.
کلیدواژه‌های انگلیسی مقاله SKC, Psychopharmacological, Neurosafety, Number of rearing
نویسندگان مقاله tarequl اسلام | tarequl islam
department of microbiology, noakhali science and technology university, sonapur-3814, noakhali, bangladesh


md saddam حسین | md saddam hussain
department of pharmacy, noakhali science and technology university, noakhali-3814,bangladesh


محمد nurul امین | mohammad nurul amin
department of pharmacy, atish dipankar university of science and technology, banani, dhaka, bangladesh


ashraful محمود tuhin | ashraful mahmud tuhin
department of pharmacy, noakhali science and technology university, sonapur-3814, noakhali, bangladesh
نشانی اینترنتی http://ajp.mums.ac.ir/article_9536.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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