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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۱، صفحات ۲۲-۲۹
عنوان فارسی
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عنوان انگلیسی The effects of hydroalcoholic extract of Allium elburzense Wendelbo bulb on dexamethasone-induced dyslipidemia, hyperglycemia, and oxidative stress in rats
چکیده انگلیسی مقاله Recent evidences have suggested the beneficial cardiovascular effects of some plants belonging to the genus Allium . The present study is an attempt to investigate the effects of hydroalcoholic extract of Allium elburzense bulb on dexamethasone-induced dyslipidemia in rats. Total phenolic content of A. elburzense bulb hydroalcoholic extract was determined using Folin-Ciocalteu method. Thirty-six male Wistar albino rats in 6 groups were studied. Group 1 (dyslipidemic control) received dexamethasone (10 mg/kg/day, s.c.) for 7 days, groups 2-4 (treated) received dexamethasone and simultaneously treated orally with 100, 200, or 400 mg/kg of A . elburzense extract, group 5 (normal control) received a single daily injection of normal saline (1 mL/kg, s.c.) and the vehicle orally, and group 6 (reference) received dexamethasone and atorvastatin (40 mg/kg) orally. At the end of experiment, blood glucose, lipid profile, and malondialdehyde (MDA) levels were assessed in serum samples. Livers were processed for histopathological examination. Total phenolic content of A. elburzense extract was estimated to be 33.52 ± 1.3% mg gallic acid equivalent/g of the dried plant extract. The plant extract significantly reduced serum blood glucose, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and MDA levels and increased the high density lipoprotein-cholesterol level and also improved liver steatosis compared to the dyslipidemic control group. These results suggest the hydroalcoholic extract of A. elburzense bulb has anti-dyslipidemic, anti-hyperglycemic, and antioxidant effects on rats receiving high doses of dexamethasone.
کلیدواژه‌های انگلیسی مقاله Allium,Hyperlipidemias,Lipid peroxidation,Dexamethasone
نویسندگان مقاله لیلا صفاییان | leila safaeian
2department of pharmacognosy, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

بهزاد ذوالفقاری | behzad zolfaghari
1department of pharmacology and toxicology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سجاد کریمی | sajad karimi
3department of pathology, school of medicine, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

اردشیر طالبی | ardeshir talebi
4isfahan center of public health training and research, institute of public health research, tehran university of medical science, tehran, i.r. iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

محمدرضا آقای قزوینی | mohammadreza aghaye ghazvini


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1803
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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