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Research Journal of Pharmacognosy، جلد ۵، شماره ۱، صفحات ۲۳-۳۰
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عنوان انگلیسی Study of wound healing potential of Stevia rebaudiana ethanol extract in male rats
چکیده انگلیسی مقاله Background and objectives: Stevia rebaudiana has been used in medicine as anti-inflammatory, antioxidant, antipyretic, anti-fungal, and antibacterial agent. The present study was conducted to investigate the healing effects of S. rebaudiana ethanol extracts on cutaneous wounds in rats. Methods: Full-thickness excisional wounds (2×2 cm) were induced on the back of 32 rats. The rats were divided into four groups as follows; untreated (control) and treated with 1 mL basal cream, 1 mL S. rebaudiana ethanol extract 10%, and 1 mL tetracycline (3%) for 20 days (short term). Animals of each group were euthanized at 20 day post-injury and wounds were assessed through macroscopic and microscopic analyses. Results: During the experiment, S. rebaudiana indicated a significant reduction in the wound area compared to other groups. Parameters such as arrangement of the healing tissue, re-epithelilization and epithelial formation demonstrated considerable changes when compared to the control. In addition, treatment with S. rebaudiana decreased the total number of cells, fibrocytes/fibroblasts ratio, neutrophils, and lymphocytes and enhanced the number of blood vessels and fibroblasts at 20 day. Conclusion: The present study demonstrated the wound healing activity of S. rebaudiana, lending credence to the folkloric use in the treatment of cutaneous wounds.
کلیدواژه‌های انگلیسی مقاله ethanol extract, in vivo, Stevia rebaudiana, wound healing
نویسندگان مقاله s گورانی |
department of toxicology, faculty of veterinary medicine, tehran, iran.

محمد مهدی زنگنه | m m
department of clinical sciences, faculty of veterinary medicine, razi university, kermanshah, iran.
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

a زنگنه |
department of microbiology section, pathobiology amp; basic sciences, faculty of veterinary medicine, razi university, kermanshah, iran.
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

c poorshamohammad |
department of clinical sciences, faculty of veterinary medicine, razi university, kermanshah, iran.
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

m آبیاری |
department of clinical sciences, faculty of veterinary medicine, razi university, kermanshah, iran.
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

r مرادی |
department of chemistry, payame noor university, tehran, iran.
سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

f نجفی |
department of dermatology, school of medicine, kermanshah university of medical sciences, kermanshah, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

r تحویلیان |
research pharmaceutical center, school of pharmacy, kermanshah university of medical sciences, kermanshah, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_54422_edc0141b28b457b6bb02aebf306b1f8d.pdf
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